DEFB127

Defensin, beta 127
Identifiers
Symbols	DEFB127; C20orf73; DEF-27; DEFB-27; DEFB27; bA530N10.2; hBD-27
External IDs	HomoloGene: 89142 GeneCards: DEFB127 Gene
Gene Ontology Cellular component • cellular_component • extracellular region Biological process • defense response to bacterium • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	140850	n/a
Ensembl	ENSG00000088782	n/a
UniProt	Q9H1M4	n/a
RefSeq (mRNA)	NM_139074	n/a
RefSeq (protein)	NP_620713	n/a
Location (UCSC)	Chr 20: 0.14 – 0.14 Mb	n/a
PubMed search	[1]	n/a

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.^[1][2]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.^[2]

References

1. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122330. 
2. ^ ^{a b} "Entrez Gene: DEFB127 defensin, beta 127". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140850. 

Further reading

• van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131–8. doi:10.1016/S0091-6749(99)70004-7. PMID 10588992. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.". Genomics 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.