Moco RNA motif

Consensus secondary structure of Moco RNAs. Layout is similar to a previously published figure.^[1]

Moco (molybdenum cofactor) riboswitch
Predicted secondary structure and sequence conservation of MOCO_RNA_motif
Identifiers
Symbol	MOCO_RNA_motif
Rfam	RF01055
Other data
RNA type	Cis-reg; riboswitch
Domain(s)	Bacteria
SO	0005836

The Moco RNA motif is a conserved RNA structure ^[2] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor ^[1]. As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches.

References

1. ^ ^{a b} Regulski EE, Moy RH, Weinberg Z, et al. (2008). "A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism". Mol. Microbiol. 68 (4): 918. doi:10.1111/j.1365-2958.2008.06208.x. PMC 2408646. PMID 18363797. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2408646. 
2. ^ Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–19. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1950547. 

External links

• Rfam page for Moco_RNA_motif