Obregón may refer to:
- Obregon, California, in Imperial County
- Álvaro Obregón, D.F., in the Mexican Federal District
- Ciudad Obregón, in the Mexican state of Sonora
- Progreso de Álvaro Obregón, in the state of Hidalgo
- Cañadas de Obregón, in the state of Jalisco
- Tekax de Álvaro Obregón, in the state of Yucatán
- Álvaro Obregón, Michoacán
- Mexico's "1911"
- The Obregon (pistol), designed by Alejandro Obregón
Comic Book Character
- Obregon Kaine, CrossGen comics character. Featured in the Negation series
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