HLA-B58

HLA-B58

Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens-Johnson syndrome.cite journal |author=Chung WH, Hung SI, Chen YT |title=Human leukocyte antigens and drug hypersensitivity |journal=Curr Opin Allergy Clin Immunol |volume=7 |issue=4 |pages=317–23 |year=2007 |month=August |pmid=17620823 |doi=10.1097/ACI.0b013e3282370c5f |url=] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).cite journal |author=Hung SI, Chung WH, Liou LB, "et al" |title=HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=11 |pages=4134–9 |year=2005 |month=March |pmid=15743917 |pmc=554812 |doi=10.1073/pnas.0409500102 |url=] The association with allopurinol sensitivity in JSJ/TEN was extremely strong in asia, and somewhat less associated in Europeans.cite journal |author=Lonjou C, Borot N, Sekula P, "et al" |title=A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs |journal=Pharmacogenet. Genomics |volume=18 |issue=2 |pages=99–107 |year=2008 |month=February |pmid=18192896 |doi=10.1097/FPC.0b013e3282f3ef9c |url=]

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