Ribonucleotide reductase M1 polypeptide, also known as RRM1, is a human gene.cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = ]

section_title =
summary_text = This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = ]

ee also

* Ribonucleotide reductase


Further reading

citations =
*cite journal | author=Pavloff N, Rivard D, Masson S, "et al." |title=Sequence analysis of the large and small subunits of human ribonucleotide reductase. |journal=DNA Seq. |volume=2 |issue= 4 |pages= 227–34 |year= 1992 |pmid= 1627826 |doi=
*cite journal | author=Byrne J, Smith P |title=Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. |journal=Hum. Genet. |volume=87 |issue= 3 |pages= 376 |year= 1991 |pmid= 1677928 |doi=
*cite journal | author=Parker NJ, Begley CG, Fox RM |title=Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes. |journal=Nucleic Acids Res. |volume=19 |issue= 13 |pages= 3741 |year= 1991 |pmid= 1840662 |doi=
*cite journal | author=Mann GJ, Musgrove EA, Fox RM, Thelander L |title=Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. |journal=Cancer Res. |volume=48 |issue= 18 |pages= 5151–6 |year= 1988 |pmid= 3044582 |doi=
*cite journal | author=Brissenden JE, Caras I, Thelander L, Francke U |title=The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. |journal=Exp. Cell Res. |volume=174 |issue= 1 |pages= 302–8 |year= 1988 |pmid= 3275546 |doi=
*cite journal | author=Engström Y, Francke U |title=Assignment of the structural gene for subunit M1 of human ribonucleotide reductase to the short arm of chromosome 11. |journal=Exp. Cell Res. |volume=158 |issue= 2 |pages= 477–83 |year= 1985 |pmid= 3891388 |doi=
*cite journal | author=Parker NJ, Begley CG, Fox RM |title=Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter. |journal=Genomics |volume=27 |issue= 2 |pages= 280–5 |year= 1995 |pmid= 7557993 |doi= 10.1006/geno.1995.1043
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Parker NJ, Begley CG, Fox RM |title=Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene. |journal=Genomics |volume=19 |issue= 1 |pages= 91–6 |year= 1994 |pmid= 8188248 |doi= 10.1006/geno.1994.1017
*cite journal | author=Byrne JA, Smith PJ |title=The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 275–7 |year= 1993 |pmid= 8386696 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bepler G, O'briant KC, Kim YC, "et al." |title=A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region. |journal=Genomics |volume=55 |issue= 2 |pages= 164–75 |year= 1999 |pmid= 9933563 |doi= 10.1006/geno.1998.5659
*cite journal | author=Pitterle DM, Kim YC, Jolicoeur EM, "et al." |title=Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1). |journal=Mamm. Genome |volume=10 |issue= 9 |pages= 916–22 |year= 1999 |pmid= 10441745 |doi=
*cite journal | author=Guittet O, Håkansson P, Voevodskaya N, "et al." |title=Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40647–51 |year= 2001 |pmid= 11517226 |doi= 10.1074/jbc.M106088200
*cite journal | author=Kashlan OB, Scott CP, Lear JD, Cooperman BS |title=A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. |journal=Biochemistry |volume=41 |issue= 2 |pages= 462–74 |year= 2002 |pmid= 11781084 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kashlan OB, Cooperman BS |title=Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences. |journal=Biochemistry |volume=42 |issue= 6 |pages= 1696–706 |year= 2003 |pmid= 12578384 |doi= 10.1021/bi020634d
*cite journal | author=Xue L, Zhou B, Liu X, "et al." |title=Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits. |journal=Cancer Res. |volume=63 |issue= 5 |pages= 980–6 |year= 2003 |pmid= 12615712 |doi=
*cite journal | author=Gautam A, Li ZR, Bepler G |title=RRM1-induced metastasis suppression through PTEN-regulated pathways. |journal=Oncogene |volume=22 |issue= 14 |pages= 2135–42 |year= 2003 |pmid= 12687015 |doi= 10.1038/sj.onc.1206232
*cite journal | author=Rosell R, Scagliotti G, Danenberg KD, "et al." |title=Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. |journal=Oncogene |volume=22 |issue= 23 |pages= 3548–53 |year= 2003 |pmid= 12789263 |doi= 10.1038/sj.onc.1206419

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