HLA-B7

In disease

Cervical cancer

HLA-B7 along with HLA-DQ8 increased risk for cervical cancer in at risk Costa Rican womencite journal |author=Wang SS, Wheeler CM, Hildesheim A, "et al" |title=Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica |journal=J. Infect. Dis. |volume=184 |issue=10 |pages=1310–4 |year=2001 |month=November |pmid=11679920 |doi= |url=http://www.journals.uchicago.edu/cgi-bin/resolve?JID010476] and Asian Indianscite journal |author=Bhattacharya P, Sengupta S |title=Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03 |journal=Tissue Antigens |volume=70 |issue=4 |pages=283–93 |year=2007 |month=October |pmid=17767549 |doi=10.1111/j.1399-0039.2007.00894.x |url=]

arcoidosis

A relationship between HLA-B7 and sarcoidosis has been known for 30+ years.cite journal |author=Rybicki BA, Iannuzzi MC |title=Sarcoidosis and human leukocyte antigen class I and II genes: it takes two to tango? |journal=Am. J. Respir. Crit. Care Med. |volume=169 |issue=6 |pages=665–6 |year=2004 |month=March |pmid=15003948 |doi=10.1164/rccm.2401005 |url=] . However the association is weak and has not been reproducible in all studies. A common serologically defined haplotype in Europeans is HLA A3-Cw7-B7-DR15-DQ6.2 which is composed of alleles A*0301:Cw*0701:B*0702:DRB1*1501:DQA1*0102:DQB1*0602. In persistent sarcoidosis this haplotype was found to be increased in sarcoidosis, and further study eliminated risk contributed by A3-Cw7 and DQ6.2 indicating B7-DR15 haplotype contains risk of disease (OR = 2.5). The region of chromosome 6 contains nearly on million nucleotides so that these genes, or a closely linked gene could be involved in disease.cite journal |author=Grunewald J, Eklund A, Olerup O |title=Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients |journal=Am. J. Respir. Crit. Care Med. |volume=169 |issue=6 |pages=696–702 |year=2004 |month=March |pmid=14656748 |doi=10.1164/rccm.200303-459OC |url=]

Juvenile Spondylarthropathies

In Croation children, two HLA-B27 alleles were found associated with disease, B*2702, B*2705.cite journal |author=Harjacek M, Margetić T, Kerhin-Brkljacić V, Martinez N, Grubić Z |title=HLA-B*27/HLA-B*07 in combination with D6S273-134 allele is associated with increased susceptibility to juvenile spondyloarthropathies |journal=Clin. Exp. Rheumatol. |volume=26 |issue=3 |pages=498–504 |year=2008 |pmid=18578977 |doi= |url=] The study showed also B*0702 in coorperation with B*27, the HLA-B*07/B*27 combination with D6S273-134 genomic marker allele and was found not to be the result of linkage disequilibrium. B*2705 was found to be dominant allele associated.

Haemochromatosis

The HFE gene responsible for haemochromatosis is distal on chromosome 6 from HLA-A and moreso from HLA-B, the distance suffices (3 million nucleotides) to allow equilibration of the loci. Nonetheless, a linkage has been found between A3-B7 haplotype and haemochromatosis. The region is almost 1.4 million nucleotides in length and contains many other genes that could be involved. A more recent study looked at a number of linked gene-alleles and found I82-2:D6S265-1:HLA-A3:D6S128-2:HLA-F1:D6S105-8 was constantly associated while B7 appeared beyond the haplotype linked to disease.cite journal |author=Raha-Chowdhury R, Bowen DJ, Burnett AK, Worwood M |title=Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis |journal=J. Med. Genet. |volume=32 |issue=6 |pages=446–52 |year=1995 |month=June |pmid=7666396 |pmc=1050484 |doi= |url=]

References