HLA-G

HLA-G histocompatibility antigen, class I, G, also known as HLA-G, or Human Leukocyte Antigen G, is a human gene.

PBB_Summary
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summary_text = HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [cite web | title = Entrez Gene: HLA-G HLA-G histocompatibility antigen, class I, G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3135| accessdate = ]

References

Further reading

*cite journal | author=Carosella ED, Favier B, Rouas-Freiss N, Moreau P, LeMaoult J |title=Beyond the increasing complexity of the immunomodulatory HLA-G molecule. |journal=Blood |volume=111 |issue= 10 |pages= 4862–70 |year= 2008 |pmid= 18334671 |doi=
*cite journal | author=Carosella ED, Moreau P, LeMaoult J, Rouas-Freiss N |title=HLA-G: From biology to clinical benefits |journal=Trends in Immunology |volume=29 |issue= |pages= 125–32 |year= 2008 |pmid= 18249584 |doi= PBB_Further_reading
citations =
*cite journal | author=Arnaiz-Villena A, Martinez-Laso J, Alvarez M, "et al." |title=Primate Mhc-E and -G alleles. |journal=Immunogenetics |volume=46 |issue= 4 |pages= 251–66 |year= 1997 |pmid= 9218527 |doi=
*cite journal | author=Le Bouteiller P |title=HLA-G in the human placenta: expression and potential functions. |journal=Biochem. Soc. Trans. |volume=28 |issue= 2 |pages= 208–12 |year= 2000 |pmid= 10816129 |doi=
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Langat DK, Hunt JS |title=Do nonhuman primates comprise appropriate experimental models for studying the function of human leukocyte antigen-G? |journal=Biol. Reprod. |volume=67 |issue= 5 |pages= 1367–74 |year= 2003 |pmid= 12390864 |doi=
*cite journal | author=Moreau P, Dausset J, Carosella ED, Rouas-Freiss N |title=Viewpoint on the functionality of the human leukocyte antigen-G null allele at the fetal-maternal interface. |journal=Biol. Reprod. |volume=67 |issue= 5 |pages= 1375–8 |year= 2003 |pmid= 12390865 |doi=
*cite journal | author=Moreau P, Rousseau P, Rouas-Freiss N, "et al." |title=HLA-G protein processing and transport to the cell surface. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 9 |pages= 1460–6 |year= 2002 |pmid= 12440768 |doi=
*cite journal | author=Greenway AL, Holloway G, McPhee DA, "et al." |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 12734410 |doi=
*cite journal | author=Bénichou S, Benmerah A |title= [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi=
*cite journal | author=Le Bouteiller P, Legrand-Abravanel F, Solier C |title=Soluble HLA-G1 at the materno-foetal interface--a review. |journal=Placenta |volume=24 Suppl A |issue= |pages= S10–5 |year= 2004 |pmid= 12842408 |doi=
*cite journal | author=Sköld M, Behar SM |title=Role of CD1d-restricted NKT cells in microbial immunity. |journal=Infect. Immun. |volume=71 |issue= 10 |pages= 5447–55 |year= 2003 |pmid= 14500461 |doi=
*cite journal | author=Wiendl H, Mitsdoerffer M, Weller M |title=Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies. |journal=Hum. Immunol. |volume=64 |issue= 11 |pages= 1050–6 |year= 2004 |pmid= 14602235 |doi=
*cite journal | author=Urosevic M, Dummer R |title=HLA-G in skin cancer: a wolf in sheep's clothing? |journal=Hum. Immunol. |volume=64 |issue= 11 |pages= 1073–80 |year= 2004 |pmid= 14602238 |doi=
*cite journal | author=Carosella ED, Moreau P, Le Maoult J, "et al." |title=HLA-G molecules: from maternal-fetal tolerance to tissue acceptance. |journal=Adv. Immunol. |volume=81 |issue= |pages= 199–252 |year= 2004 |pmid= 14711057 |doi=
*cite journal | author=Leavitt SA, SchOn A, Klein JC, "et al." |title=Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. |journal=Curr. Protein Pept. Sci. |volume=5 |issue= 1 |pages= 1–8 |year= 2004 |pmid= 14965316 |doi=
*cite journal | author=Le Maoult J, Rouas-Freiss N, Le Discorde M, "et al." |title= [HLA-G in organ transplantation] |journal=Pathol. Biol. |volume=52 |issue= 2 |pages= 97–103 |year= 2004 |pmid= 15001239 |doi= 10.1016/j.patbio.2003.04.006
*cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, "et al." |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141–51 |year= 2004 |pmid= 15078178 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
*cite journal | author=McIntire RH, Hunt JS |title=Antigen presenting cells and HLA-G--a review. |journal=Placenta |volume=26 Suppl A |issue= |pages= S104–9 |year= 2005 |pmid= 15837058 |doi= 10.1016/j.placenta.2005.01.006
*cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 16091223 |doi=

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