- STAB2
Stabilin 2, also known as STAB2, is a human
gene .cite web | title = Entrez Gene: STAB2 stabilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55576| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.cite web | title = Entrez Gene: STAB2 stabilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55576| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Politz O, Gratchev A, McCourt PA, "et al." |title=Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. |journal=Biochem. J. |volume=362 |issue= Pt 1 |pages= 155–64 |year= 2002 |pmid= 11829752 |doi=
*cite journal | author=Adachi H, Tsujimoto M |title=FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34264–70 |year= 2002 |pmid= 12077138 |doi= 10.1074/jbc.M204277200
*cite journal | author=Tamura Y, Adachi H, Osuga J, "et al." |title=FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12613–7 |year= 2003 |pmid= 12473645 |doi= 10.1074/jbc.M210211200
*cite journal | author=Zhou B, McGary CT, Weigel JA, "et al." |title=Purification and molecular identification of the human hyaluronan receptor for endocytosis. |journal=Glycobiology |volume=13 |issue= 5 |pages= 339–49 |year= 2004 |pmid= 12626425 |doi= 10.1093/glycob/cwg029
*cite journal | author=Smedsrød B, Johansson S, Goerdt S |title=Shooting HARE. |journal=Glycobiology |volume=13 |issue= 5 |pages= 11G–12G; author reply 12G |year= 2004 |pmid= 12751488 |doi=
*cite journal | author=Dobreva G, Dambacher J, Grosschedl R |title=SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. |journal=Genes Dev. |volume=17 |issue= 24 |pages= 3048–61 |year= 2004 |pmid= 14701874 |doi= 10.1101/gad.1153003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Harris EN, Weigel JA, Weigel PH |title=Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE). |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36201–9 |year= 2004 |pmid= 15208308 |doi= 10.1074/jbc.M405322200
*cite journal | author=Hansen B, Longati P, Elvevold K, "et al." |title=Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. |journal=Exp. Cell Res. |volume=303 |issue= 1 |pages= 160–73 |year= 2005 |pmid= 15572036 |doi= 10.1016/j.yexcr.2004.09.017
*cite journal | author=Harris EN, Kyosseva SV, Weigel JA, Weigel PH |title=Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). |journal=J. Biol. Chem. |volume=282 |issue= 5 |pages= 2785–97 |year= 2007 |pmid= 17145755 |doi= 10.1074/jbc.M607787200PBB_Controls
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