- LIN28
Lin-28 homolog (C. elegans), also known as LIN28, is a human
gene .cite web | title = Entrez Gene: LIN28 lin-28 homolog (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79727| accessdate = ] It is marker of undifferentiated human embryonic stem cells [Richards M, et al. | The transcriptome profile of human embryonic stem cells as defined by SAGE. | Stem Cells 22:51-64, 2004 | PMID 14688391] and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. [Yu J, et al. | Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells | Science DOI: 10.1126/science.1151526 | PMID 18033853] It encodes a cytoplasmic mRNA-binding protein [Balzer E, Moss EG. | Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.| RNA Biology 4:16-25, 2007.| PMID 17617744] that binds to and enhances the translation of the Igf2 mRNA. [Polesskaya A, et al. | Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency | Genes & Development 21:1125-1138, 2007 | PMID 17473174] . Lin28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells [ Viswanathan S, et al. Selective Blockade of MicroRNA Processing by Lin28 | Science 320:97-100, 2008 | ] .PBB_Summary
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summary_text =References
*cite journal |journal=Science |volume=320 |pages=98–100 |year=2008 |title="Selective Blockade of MicroRNA Processing by Lin28"
Further reading
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citations =
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moss EG, Tang L |title=Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. |journal=Dev. Biol. |volume=258 |issue= 2 |pages= 432–42 |year= 2003 |pmid= 12798299 |doi=
*cite journal | author=Richards M, Tan SP, Tan JH, "et al." |title=The transcriptome profile of human embryonic stem cells as defined by SAGE. |journal=Stem Cells |volume=22 |issue= 1 |pages= 51–64 |year= 2004 |pmid= 14688391 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sempere LF, Freemantle S, Pitha-Rowe I, "et al." |title=Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. |journal=Genome Biol. |volume=5 |issue= 3 |pages= R13 |year= 2004 |pmid= 15003116 |doi= 10.1186/gb-2004-5-3-r13
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gerecht-Nir S, Dazard JE, Golan-Mashiach M, "et al." |title=Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. |journal=Dev. Dyn. |volume=232 |issue= 2 |pages= 487–97 |year= 2005 |pmid= 15614775 |doi= 10.1002/dvdy.20247
*cite journal | author=Lee YS, Kim HK, Chung S, "et al." |title=Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 16635–41 |year= 2005 |pmid= 15722555 |doi= 10.1074/jbc.M412247200
*cite journal | author=Wu L, Belasco JG |title=Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells. |journal=Mol. Cell. Biol. |volume=25 |issue= 21 |pages= 9198–208 |year= 2005 |pmid= 16227573 |doi= 10.1128/MCB.25.21.9198-9208.2005
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727PBB_Controls
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