COX6A1

Cytochrome c oxidase subunit VIa polypeptide 1, also known as COX6A1, is a human gene.cite web | title = Entrez Gene: COX6A1 cytochrome c oxidase subunit VIa polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1337| accessdate = ]

PBB_Summary
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summary_text = Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.cite web | title = Entrez Gene: COX6A1 cytochrome c oxidase subunit VIa polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1337| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=
*cite journal | author=Fabrizi GM, Sadlock J, Hirano M, "et al." |title=Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. |journal=Gene |volume=119 |issue= 2 |pages= 307–12 |year= 1992 |pmid= 1327966 |doi=
*cite journal | author=Fabrizi GM, Rizzuto R, Nakase H, "et al." |title=Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase. |journal=Nucleic Acids Res. |volume=17 |issue= 15 |pages= 6409 |year= 1989 |pmid= 2549515 |doi=
*cite journal | author=Schmidt TR, Jaradat SA, Goodman M, "et al." |title=Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. |journal=Mol. Biol. Evol. |volume=14 |issue= 6 |pages= 595–601 |year= 1997 |pmid= 9190060 |doi=
*cite journal | author=Merante F, Ling M, Duncan AM, "et al." |title=Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes. |journal=Genome |volume=40 |issue= 3 |pages= 325–31 |year= 1997 |pmid= 9202413 |doi=
*cite journal | author=Hey Y, Hoggard N, Burt E, "et al." |title=Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 167–8 |year= 1997 |pmid= 9284905 |doi=
*cite journal | author=Wong-Riley M, Guo A, Bachman NJ, Lomax MI |title=Human COX6A1 gene: promoter analysis, cDNA isolation and expression in the monkey brain. |journal=Gene |volume=247 |issue= 1-2 |pages= 63–75 |year= 2000 |pmid= 10773445 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Scherer SE, Muzny DM, Buhay CJ, "et al." |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569

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