COX5B

Cytochrome c oxidase subunit Vb, also known as COX5B, is a human gene.cite web | title = Entrez Gene: COX5B cytochrome c oxidase subunit Vb| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1329| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.cite web | title = Entrez Gene: COX5B cytochrome c oxidase subunit Vb| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1329| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lomax MI, Hsieh CL, Darras BT, Francke U |title=Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. |journal=Genomics |volume=10 |issue= 1 |pages= 1–9 |year= 1991 |pmid= 1646156 |doi=
*cite journal | author=Romero N, Marsac C, Fardeau M, "et al." |title=Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle. |journal=Histochemistry |volume=94 |issue= 2 |pages= 211–5 |year= 1990 |pmid= 2162812 |doi=
*cite journal | author=Zeviani M, Sakoda S, Sherbany AA, "et al." |title=Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase. |journal=Gene |volume=65 |issue= 1 |pages= 1–11 |year= 1988 |pmid= 2840351 |doi=
*cite journal | author=Hughes GJ, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216–22 |year= 1994 |pmid= 8313870 |doi=
*cite journal | author=Bachman NJ, Yang TL, Dasen JS, "et al." |title=Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. |journal=Arch. Biochem. Biophys. |volume=333 |issue= 1 |pages= 152–62 |year= 1996 |pmid= 8806766 |doi= 10.1006/abbi.1996.0376
*cite journal | author=Lefai E, Vincent A, Boespflug-Tanguy O, "et al." |title=Quantitative decrease of human cytochrome c oxidase during development: evidences for a post-transcriptional regulation. |journal=Biochim. Biophys. Acta |volume=1318 |issue= 1-2 |pages= 191–201 |year= 1997 |pmid= 9030264 |doi=
*cite journal | author=Wu H, Rao GN, Dai B, Singh P |title=Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32491–8 |year= 2000 |pmid= 10915781 |doi= 10.1074/jbc.M002458200
*cite journal | author=Beauchemin AM, Gottlieb B, Beitel LK, "et al." |title=Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. |journal=Brain Res. Bull. |volume=56 |issue= 3-4 |pages= 285–97 |year= 2002 |pmid= 11719263 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00663 Cytochrome c oxidase subunit Vb] in PROSITE

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