BAZ1A

Bromodomain adjacent to zinc finger domain, 1A, also known as BAZ1A, is a human gene.cite web | title = Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11177| accessdate = ] cite journal | author = Jones MH, Hamana N, Nezu J, Shimane M | title = A novel family of bromodomain genes | journal = Genomics | volume = 63 | issue = 1 | pages = 40–5 | year = 2000 | month = January | pmid = 10662543 | doi = 10.1006/geno.1999.6071 | url = | issn = ]

tructure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:

* N-terminus – PHD finger (C4HC3 zinc finger)
* WAKZ motif
* LH (leucine-rich helical domain) motif
* C-terminus – bromodomain

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.cite journal | author = Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R | title = A family of chromatin remodeling factors related to Williams syndrome transcription factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1038–43 | year = 2000 | month = February | pmid = 10655480 | pmc = 15513 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10655480 | issn = ] cite journal | author = Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J. | volume = 19 | issue = 13 | pages = 3377–87 | year = 2000 | month = July | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 | url = | issn = ]

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array and the spacing activity is ATP-dependent. Furthermore the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.cite journal | author = Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD | title = An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin | journal = Nat. Genet. | volume = 32 | issue = 4 | pages = 627–32 | year = 2002 | month = December | pmid = 12434153 | doi = 10.1038/ng1046 | url = | issn = ]

References

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