UNC5C

Unc-5 homolog C (C. elegans), also known as UNC5C, is a human gene.cite web | title = Entrez Gene: UNC5C unc-5 homolog C (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8633| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.cite web | title = Entrez Gene: UNC5C unc-5 homolog C (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8633| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kennedy TE |title=Cellular mechanisms of netrin function: long-range and short-range actions. |journal=Biochem. Cell Biol. |volume=78 |issue= 5 |pages= 569–75 |year= 2001 |pmid= 11103947 |doi=
*cite journal | author=Livesey FJ |title=Netrins and netrin receptors. |journal=Cell. Mol. Life Sci. |volume=56 |issue= 1-2 |pages= 62–8 |year= 2001 |pmid= 11213262 |doi=
*cite journal | author=Leonardo ED, Hinck L, Masu M, "et al." |title=Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. |journal=Nature |volume=386 |issue= 6627 |pages= 833–8 |year= 1997 |pmid= 9126742 |doi= 10.1038/386833a0
*cite journal | author=Ackerman SL, Knowles BB |title=Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. |journal=Genomics |volume=52 |issue= 2 |pages= 205–8 |year= 1998 |pmid= 9782087 |doi= 10.1006/geno.1998.5425
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Thiebault K, Mazelin L, Pays L, "et al." |title=The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4173–8 |year= 2003 |pmid= 12655055 |doi= 10.1073/pnas.0738063100
*cite journal | author=Geisbrecht BV, Dowd KA, Barfield RW, "et al." |title=Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 32561–8 |year= 2003 |pmid= 12810718 |doi= 10.1074/jbc.M302943200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kruger RP, Lee J, Li W, Guan KL |title=Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. |journal=J. Neurosci. |volume=24 |issue= 48 |pages= 10826–34 |year= 2005 |pmid= 15574733 |doi= 10.1523/JNEUROSCI.3715-04.2004
*cite journal | author=Llambi F, Lourenço FC, Gozuacik D, "et al." |title=The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1192–201 |year= 2005 |pmid= 15729359 |doi= 10.1038/sj.emboj.7600584
*cite journal | author=Li W, Aurandt J, Jürgensen C, "et al." |title=FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. |journal=J. Cell. Sci. |volume=119 |issue= Pt 1 |pages= 47–55 |year= 2006 |pmid= 16371650 |doi= 10.1242/jcs.02697
*cite journal | author=Bernet A, Mazelin L, Coissieux MM, "et al." |title=Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. |journal=Gastroenterology |volume=133 |issue= 6 |pages= 1840–8 |year= 2008 |pmid= 17967459 |doi= 10.1053/j.gastro.2007.08.009

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes