VPS18

Vacuolar protein sorting 18 homolog (S. cerevisiae), also known as VPS18, is a human gene.cite web | title = Entrez Gene: VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57617| accessdate = ]

PBB_Summary
section_title =
summary_text = Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.cite web | title = Entrez Gene: VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57617| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Huizing M, Didier A, Walenta J, "et al." |title=Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33. |journal=Gene |volume=264 |issue= 2 |pages= 241–7 |year= 2001 |pmid= 11250079 |doi=
*cite journal | author=Kim BY, Krämer H, Yamamoto A, "et al." |title=Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29393–402 |year= 2001 |pmid= 11382755 |doi= 10.1074/jbc.M101778200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kim BY, Ueda M, Kominami E, "et al." |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577–82 |year= 2004 |pmid= 14623309 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Yogosawa S, Hatakeyama S, Nakayama KI, "et al." |title=Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41619–27 |year= 2006 |pmid= 16203730 |doi= 10.1074/jbc.M508397200
*cite journal | author=Yogosawa S, Kawasaki M, Wakatsuki S, "et al." |title=Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 1 |pages= 82–90 |year= 2006 |pmid= 16996030 |doi= 10.1016/j.bbrc.2006.09.013
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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