SULF2

Sulfatase 2, also known as SULF2, is a human gene.cite web | title = Entrez Gene: SULF2 sulfatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55959| accessdate = ]

PBB_Summary
section_title =
summary_text = Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005). [supplied by OMIM] cite web | title = Entrez Gene: SULF2 sulfatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55959| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Nagase T, Ishikawa K, Kikuno R, "et al." |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=
*cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, "et al." |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Morimoto-Tomita M, Uchimura K, Werb Z, "et al." |title=Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49175–85 |year= 2003 |pmid= 12368295 |doi= 10.1074/jbc.M205131200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dai Y, Yang Y, MacLeod V, "et al." |title=HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40066–73 |year= 2006 |pmid= 16192265 |doi= 10.1074/jbc.M508136200
*cite journal | author=Morimoto-Tomita M, Uchimura K, Bistrup A, "et al." |title=Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer. |journal=Neoplasia |volume=7 |issue= 11 |pages= 1001–10 |year= 2006 |pmid= 16331886 |doi=
*cite journal | author=Uchimura K, Morimoto-Tomita M, Bistrup A, "et al." |title=HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. |journal=BMC Biochem. |volume=7 |issue= |pages= 2 |year= 2006 |pmid= 16417632 |doi= 10.1186/1471-2091-7-2

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