STK39

Serine threonine kinase 39 (STE20/SPS1 homolog, yeast), also known as STK39, is a human gene.cite web | title = Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27347| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.cite web | title = Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27347| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Johnston AM, Naselli G, Gonez LJ, "et al." |title=SPAK, an STE20/SPS1-related kinase that activates the p38 pathway. |journal=Oncogene |volume=19 |issue= 37 |pages= 4290–7 |year= 2000 |pmid= 10980603 |doi= 10.1038/sj.onc.1203784
*cite journal | author=Qi H, Labrie Y, Grenier J, "et al." |title=Androgens induce expression of SPAK, an STE20/SPS1-related kinase, in LNCaP human prostate cancer cells. |journal=Mol. Cell. Endocrinol. |volume=182 |issue= 2 |pages= 181–92 |year= 2001 |pmid= 11514053 |doi=
*cite journal | author=Dowd BF, Forbush B |title=PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27347–53 |year= 2003 |pmid= 12740379 |doi= 10.1074/jbc. M301899200
*cite journal | author=Piechotta K, Garbarini N, England R, Delpire E |title=Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52848–56 |year= 2004 |pmid= 14563843 |doi= 10.1074/jbc. M309436200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Moriguchi T, Urushiyama S, Hisamoto N, "et al." |title=WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42685–93 |year= 2006 |pmid= 16263722 |doi= 10.1074/jbc. M510042200
*cite journal | author=Vitari AC, Thastrup J, Rafiqi FH, "et al." |title=Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. |journal=Biochem. J. |volume=397 |issue= 1 |pages= 223–31 |year= 2006 |pmid= 16669787 |doi= 10.1042/BJ20060220
*cite journal | author=Polek TC, Talpaz M, Spivak-Kroizman TR |title=TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 3 |pages= 1016–24 |year= 2006 |pmid= 16950202 |doi= 10.1016/j.bbrc.2006.08.118
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, "in vivo", and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Yan Y, Nguyen H, Dalmasso G, "et al." |title=Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. |journal=Biochim. Biophys. Acta |volume=1769 |issue= 2 |pages= 106–16 |year= 2007 |pmid= 17321610 |doi= 10.1016/j.bbaexp.2007.01.003

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