PTF1A

Pancreas specific transcription factor, 1a, also known as PTF1A, is a human gene.cite web | title = Entrez Gene: PTF1A pancreas specific transcription factor, 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=256297| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.cite web | title = Entrez Gene: PTF1A pancreas specific transcription factor, 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=256297| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sommer L, Hagenbüchle O, Wellauer PK, Strubin M |title=Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence. |journal=Cell |volume=67 |issue= 5 |pages= 987–94 |year= 1992 |pmid= 1720355 |doi=
*cite journal | author=Roux E, Strubin M, Hagenbüchle O, Wellauer PK |title=The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA. |journal=Genes Dev. |volume=3 |issue= 10 |pages= 1613–24 |year= 1990 |pmid= 2612907 |doi=
*cite journal | author=Knöfler M, Krapp A, Hagenbüchle O, Wellauer PK |title=Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 21993–2002 |year= 1996 |pmid= 8703005 |doi=
*cite journal | author=Krapp A, Knöfler M, Frutiger S, "et al." |title=The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. |journal=EMBO J. |volume=15 |issue= 16 |pages= 4317–29 |year= 1996 |pmid= 8861960 |doi=
*cite journal | author=Krapp A, Knöfler M, Ledermann B, "et al." |title=The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. |journal=Genes Dev. |volume=12 |issue= 23 |pages= 3752–63 |year= 1999 |pmid= 9851981 |doi=
*cite journal | author=Adell T, Gómez-Cuadrado A, Skoudy A, "et al." |title=Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells. |journal=Cell Growth Differ. |volume=11 |issue= 3 |pages= 137–47 |year= 2000 |pmid= 10768861 |doi=
*cite journal | author=Kawaguchi Y, Cooper B, Gannon M, "et al." |title=The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. |journal=Nat. Genet. |volume=32 |issue= 1 |pages= 128–34 |year= 2002 |pmid= 12185368 |doi= 10.1038/ng959
*cite journal | author=McLellan AS, Langlands K, Kealey T |title=Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. |journal=Gene Expr. Patterns |volume=2 |issue= 3-4 |pages= 329–35 |year= 2003 |pmid= 12617822 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Sellick GS, Barker KT, Stolte-Dijkstra I, "et al." |title=Mutations in PTF1A cause pancreatic and cerebellar agenesis. |journal=Nat. Genet. |volume=36 |issue= 12 |pages= 1301–5 |year= 2005 |pmid= 15543146 |doi= 10.1038/ng1475
*cite journal | author=Beres TM, Masui T, Swift GH, "et al." |title=PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. |journal=Mol. Cell. Biol. |volume=26 |issue= 1 |pages= 117–30 |year= 2006 |pmid= 16354684 |doi= 10.1128/MCB.26.1.117-130.2006
*cite journal | author=Yamada M, Terao M, Terashima T, "et al." |title=Origin of climbing fiber neurons and their developmental dependence on Ptf1a. |journal=J. Neurosci. |volume=27 |issue= 41 |pages= 10924–34 |year= 2007 |pmid= 17928434 |doi= 10.1523/JNEUROSCI.1423-07.2007

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