RASGRP1

Ras guanyl releasing protein 1 (calcium and DAG-regulated), also known as RasGRP1, is a human gene.cite web | title = Entrez Gene: RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10125| accessdate = ]

PBB_Summary
section_title =
summary_text = RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. The corresponding rat gene rbc7, which lacks a 5-prime exon, represents a 5-prime and 3-prime truncated version of a larger normal rat transcript that encodes a predicted 90-kD protein. This shorter transcript has not been found in humans.cite web | title = Entrez Gene: RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10125| accessdate = ]

References

Further reading

*cite journal | author=Dower NA, Stang SL, Bottorff DA, Ebinu JO, Dickie P, Ostergaard HJ, Stone JC |title=RasGRP is essential for mouse thymocyte differentiation and TCR signaling. |journal=Nature Immunology |volume=1 |issue= 4 |pages= 317–21 |year= 2000 |pmid= 11017103 |doi=
*cite journal | author=Priatel JJ, Teh SJ, Dower NA, Stone JC, "et al." |title=RasGRP1 Transduces Low-Grade TCR Signals Which Are Critical For T Cell Development, Homeostasis and Differentiation. |journal=Immunity |volume=17 |issue= 5 |pages= 617–27 |year= 2002 |pmid= 12433368 |doi=
*cite journal | author=Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS "et al." |title=Chronic Immunodeficiency in Mice Lacking RasGRP1 Results in CD4 T Cell Immune Activation and Exhaustion. |journal=J. Immunol. |volume=179 |issue= 4 |pages= 2143–52 |year= 2007 |pmid= 17675473 |doi=
*cite journal | author=Priatel JJ, Chen X, Dhanji S, Abraham N, "et al." |title=RasGRP1 Transmits Pro-Differentiation TCR Signaling that is Crucial for CD4 T Cell Development. |journal=J. Immunol. |volume=177 |issue= 3 |pages= 1470–80 |year= 2006 |pmid= 16849453 |doi= PBB_Further_reading
citations =
*cite journal | author=Ebinu JO, Bottorff DA, Chan EY, "et al." |title=RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. |journal=Science |volume=280 |issue= 5366 |pages= 1082–6 |year= 1998 |pmid= 9582122 |doi=
*cite journal | author=Kawasaki H, Springett GM, Toki S, "et al." |title=A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13278–83 |year= 1998 |pmid= 9789079 |doi=
*cite journal | author=Bottorff D, Ebinu J, Stone JC |title=RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. |journal=Mamm. Genome |volume=10 |issue= 4 |pages= 358–61 |year= 1999 |pmid= 10087292 |doi=
*cite journal | author=Topham MK, Prescott SM |title=Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. |journal=J. Cell Biol. |volume=152 |issue= 6 |pages= 1135–43 |year= 2001 |pmid= 11257115 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bivona TG, Pérez De Castro I, Ahearn IM, "et al." |title=Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. |journal=Nature |volume=424 |issue= 6949 |pages= 694–8 |year= 2003 |pmid= 12845332 |doi= 10.1038/nature01806
*cite journal | author=Madani S, Hichami A, Cherkaoui-Malki M, "et al." |title=Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1176–83 |year= 2004 |pmid= 14583629 |doi= 10.1074/jbc.M306252200
*cite journal | author=Klinger MB, Guilbault B, Goulding RE, Kay RJ |title=Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. |journal=Oncogene |volume=24 |issue= 16 |pages= 2695–704 |year= 2005 |pmid= 15829980 |doi= 10.1038/sj.onc.1208334
*cite journal | author=Liu Y, Zhu M, Nishida K, "et al." |title=An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. |journal=J. Exp. Med. |volume=204 |issue= 1 |pages= 93–103 |year= 2007 |pmid= 17190838 |doi= 10.1084/jem.20061598
*cite journal | author=Roose JP, Mollenauer M, Ho M, "et al." |title=Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. |journal=Mol. Cell. Biol. |volume=27 |issue= 7 |pages= 2732–45 |year= 2007 |pmid= 17283063 |doi= 10.1128/MCB.01882-06
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Pasvolsky R, Feigelson SW, Kilic SS, "et al." |title=A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. |journal=J. Exp. Med. |volume=204 |issue= 7 |pages= 1571–82 |year= 2007 |pmid= 17576779 |doi= 10.1084/jem.20070058
*cite journal | author=Kosco KA, Cerignoli F, Williams S, "et al." |title=SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. |journal=Mol. Immunol. |volume=45 |issue= 2 |pages= 510–22 |year= 2007 |pmid= 17658605 |doi= 10.1016/j.molimm.2007.05.024
*cite journal | author=Yasuda S, Stevens RL, Terada T, "et al." |title=Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4890–900 |year= 2007 |pmid= 17878389 |doi=

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