SKAP1

Src kinase associated phosphoprotein 1, also known as SKAP1, is a human gene.cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.cite web | title = Entrez Gene: SKAP1 src kinase associated phosphoprotein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8631| accessdate = ]

The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection [cite journal | author=Wang H, Moon EY, Azouz A, "et al." |title=SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. |journal=Nat. Immunol. |volume=4 |issue= 4 |pages= 366–74 |year= 2003 |pmid= 12652296 |doi= 10.1038/ni913 ] and by the SKAP1 deficient mouse [Wang H, Liu H, Lu Y, Lovatt M, Wei, B, Rudd CE Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion, Mol. Cell. Biol. 2007 27, 6863-75. ] . Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells [*cite journal | author=Kosco KA, Cerignoli F, Williams S, "et al." |title=SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. |journal=Mol. Immunol. |volume=45 |issue= 2 |pages= 510–22 |year= 2008 |pmid= 17658605 |doi= 10.1016/j.molimm.2007.05.024 ] [Schneider H., Wang H., Raab M., Valk E., Smith X. , Lovatt M., Wu Z., Strebhardt K, Rudd, CE. Adaptor SKAP55 binds RasGRP1 and negatively regulates p21ras and the ERK pathway in T-cells. (2008) PLoS ONE. 3, 1718.] .

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schraven B, Marie-Cardine A, Koretzky G |title=Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling. |journal=Immunol. Lett. |volume=57 |issue= 1-3 |pages= 165–9 |year= 1997 |pmid= 9232446 |doi=
*cite journal | author=Clements JL, Boerth NJ, Lee JR, Koretzky GA |title=Integration of T cell receptor-dependent signaling pathways by adapter proteins. |journal=Annu. Rev. Immunol. |volume=17 |issue= |pages= 89–108 |year= 1999 |pmid= 10358754 |doi= 10.1146/annurev.immunol.17.1.89
*cite journal | author=Marie-Cardine A, Bruyns E, Eckerskorn C, "et al." |title=Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16077–80 |year= 1997 |pmid= 9195899 |doi=
*cite journal | author=Liu J, Kang H, Raab M, "et al." |title=FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8779–84 |year= 1998 |pmid= 9671755 |doi=
*cite journal | author=Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, "et al." |title=Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25789–95 |year= 1998 |pmid= 9748251 |doi=
*cite journal | author=Kouroku Y, Soyama A, Fujita E, "et al." |title=RA70 is a src kinase-associated protein expressed ubiquitously. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 3 |pages= 738–42 |year= 1999 |pmid= 9837776 |doi= 10.1006/bbrc.1998.9637
*cite journal | author=Kang H, Freund C, Duke-Cohan JS, "et al." |title=SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. |journal=EMBO J. |volume=19 |issue= 12 |pages= 2889–99 |year= 2000 |pmid= 10856234 |doi= 10.1093/emboj/19.12.2889
*cite journal | author=Wu L, Fu J, Shen SH |title=SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2673–86 |year= 2002 |pmid= 11909961 |doi=
*cite journal | author=Wu L, Yu Z, Shen SH |title=SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40420–7 |year= 2002 |pmid= 12171928 |doi= 10.1074/jbc.M206023200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huang Y, Norton DD, Precht P, "et al." |title=Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23576–83 |year= 2005 |pmid= 15849195 |doi= 10.1074/jbc.M413201200
*cite journal | author=Jo EK, Wang H, Rudd CE |title=An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. |journal=J. Exp. Med. |volume=201 |issue= 11 |pages= 1733–9 |year= 2005 |pmid= 15939789 |doi= 10.1084/jem.20042577
*cite journal | author=Duke-Cohan JS, Kang H, Liu H, Rudd CE |title=Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. |journal=J. Biol. Chem. |volume=281 |issue= 19 |pages= 13743–50 |year= 2006 |pmid= 16461356 |doi= 10.1074/jbc.M508774200
*cite journal | author=Kliche S, Breitling D, Togni M, "et al." |title=The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. |journal=Mol. Cell. Biol. |volume=26 |issue= 19 |pages= 7130–44 |year= 2006 |pmid= 16980616 |doi= 10.1128/MCB.00331-06

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