RGS18

Regulator of G-protein signalling 18, also known as RGS18, is a human gene.cite web | title = Entrez Gene: RGS18 regulator of G-protein signalling 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: RGS18 regulator of G-protein signalling 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Park IK, Klug CA, Li K, "et al." |title=Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 915–23 |year= 2001 |pmid= 11042171 |doi= 10.1074/jbc.M005947200
*cite journal | author=Nagata Y, Oda M, Nakata H, "et al." |title=A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. |journal=Blood |volume=97 |issue= 10 |pages= 3051–60 |year= 2001 |pmid= 11342430 |doi=
*cite journal | author=Yowe D, Weich N, Prabhudas M, "et al." |title=RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. |journal=Biochem. J. |volume=359 |issue= Pt 1 |pages= 109–18 |year= 2003 |pmid= 11563974 |doi=
*cite journal | author=Sierra DA, Gilbert DJ, Householder D, "et al." |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693
*cite journal | author=Gagnon AW, Murray DL, Leadley RJ |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets. |journal=Cell. Signal. |volume=14 |issue= 7 |pages= 595–606 |year= 2002 |pmid= 11955952 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Larminie C, Murdock P, Walhin JP, "et al." |title=Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. |journal=Brain Res. Mol. Brain Res. |volume=122 |issue= 1 |pages= 24–34 |year= 2004 |pmid= 14992813 |doi= 10.1016/j.molbrainres.2003.11.014
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Aldenhoven J, Chen Y, Moran C |title=Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels. |journal=Cytogenet. Genome Res. |volume=112 |issue= 3-4 |pages= 341F |year= 2006 |pmid= 16484797 |doi= 10.1159/000089896
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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