ALS2CR2

Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, also known as ALS2CR2, is a human gene.cite web | title = Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55437| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.cite web | title = Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55437| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Alessi DR, Sakamoto K, Bayascas JR |title=LKB1-dependent signaling pathways. |journal=Annu. Rev. Biochem. |volume=75 |issue= |pages= 137–63 |year= 2007 |pmid= 16756488 |doi= 10.1146/annurev.biochem.75.103004.142702
*cite journal | author=Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR |title=Emerging roles of pseudokinases. |journal=Trends Cell Biol. |volume=16 |issue= 9 |pages= 443–52 |year= 2006 |pmid= 16879967 |doi= 10.1016/j.tcb.2006.07.003
*cite journal | author=Hadano S, Yanagisawa Y, Skaug J, "et al." |title=Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. |journal=Genomics |volume=71 |issue= 2 |pages= 200–13 |year= 2001 |pmid= 11161814 |doi= 10.1006/geno.2000.6392
*cite journal | author=Sanna MG, da Silva Correia J, Luo Y, "et al." |title=ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30454–62 |year= 2002 |pmid= 12048196 |doi= 10.1074/jbc.M203312200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nishigaki K, Thompson D, Yugawa T, "et al." |title=Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 13520–30 |year= 2003 |pmid= 12574163 |doi= 10.1074/jbc.M208601200
*cite journal | author=Boudeau J, Baas AF, Deak M, "et al." |title=MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. |journal=EMBO J. |volume=22 |issue= 19 |pages= 5102–14 |year= 2003 |pmid= 14517248 |doi= 10.1093/emboj/cdg490
*cite journal | author=Brajenovic M, Joberty G, Küster B, "et al." |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804–11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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