SNX5

Sorting nexin 5, also known as SNX5, is a human gene.cite web | title = Entrez Gene: SNX5 sorting nexin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27131| accessdate = ]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex,cite journal | author = Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ | title = A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer | journal = J. Cell. Sci. | volume = 120 | issue = Pt 1 | pages = 45–54 | year = 2007 | pmid = 17148574 | doi = 10.1242/jcs.03302 ] which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.cite web | title = Entrez Gene: SNX5 sorting nexin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Otsuki T, Kajigaya S, Ozawa K, Liu JM |title=SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. |journal=Biochem. Biophys. Res. Commun. |volume=265 |issue= 3 |pages= 630–5 |year= 2000 |pmid= 10600472 |doi= 10.1006/bbrc.1999.1731
*cite journal | author=Teasdale RD, Loci D, Houghton F, "et al." |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7–16 |year= 2001 |pmid= 11485546 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Towler MC, Gleeson PA, Hoshino S, "et al." |title=Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. |journal=Mol. Biol. Cell |volume=15 |issue= 7 |pages= 3181–95 |year= 2005 |pmid= 15133132 |doi= 10.1091/mbc.E04-03-0249
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Merino-Trigo A, Kerr MC, Houghton F, "et al." |title=Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 26 |pages= 6413–24 |year= 2005 |pmid= 15561769 |doi= 10.1242/jcs.01561
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Wassmer T, Attar N, Bujny MV, "et al." |title=A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. |journal=J. Cell. Sci. |volume=120 |issue= Pt 1 |pages= 45–54 |year= 2007 |pmid= 17148574 |doi= 10.1242/jcs.03302

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