DHR1 domain

DHR1 (DOCK homology region 1), also known as CZH1 or Docker1, is a protein domain of approximately 200-250 amino acids that is present in the DOCK family of signalling proteins.^[1] This domain binds phospholipids and so may assist in recruitment to cellular membranes.^[2] There is evidence that this domain may also mediate protein-protein interactions.^[3]

References

1. ^ Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241. 
2. ^ Côté JF, Motoyama AB, Bush JA, Vuori K (August 2005). "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling". Nat. Cell Biol. 7 (8): 797–807. doi:10.1038/ncb1280. PMC 1352170. PMID 16025104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1352170. 
3. ^ Hara S, Kiyokawa E, Iemura SI et al. (July 2008). "The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport". Mol. Biol. Cell (Article in press) (9): 3823–35. doi:10.1091/mbc.E08-03-0314. PMC 2526700. PMID 18596235. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2526700. 

Further reading

• Côté JF, Vuori K (2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077. 
• Côté JF, Vuori K (2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends Cell Biol. 17 (8): 383–93. doi:10.1016/j.tcb.2007.05.001. PMC 2887429. PMID 17765544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2887429.