- PKD2L1
Polycystic kidney disease 2-like 1, also known as PKD2L1, is a human
gene .cite web | title = Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9033| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.cite web | title = Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9033| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Geng L, Okuhara D, Yu Z, "et al." |title=Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. |journal=J. Cell. Sci. |volume=119 |issue= Pt 7 |pages= 1383–95 |year= 2006 |pmid= 16537653 |doi= 10.1242/jcs.02818
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li Q, Liu Y, Shen PY, "et al." |title=Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7618–25 |year= 2003 |pmid= 12809519 |doi= 10.1021/bi034210a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li Q, Liu Y, Zhao W, Chen XZ |title=The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. |journal=FEBS Lett. |volume=516 |issue= 1-3 |pages= 270–8 |year= 2002 |pmid= 11959145 |doi=
*cite journal | author=Basora N, Nomura H, Berger UV, "et al." |title=Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 2 |pages= 293–301 |year= 2002 |pmid= 11805156 |doi=
*cite journal | author=Stayner C, Zhou J |title=Polycystin channels and kidney disease. |journal=Trends Pharmacol. Sci. |volume=22 |issue= 11 |pages= 543–6 |year= 2001 |pmid= 11698076 |doi=
*cite journal | author=Guo L, Chen M, Basora N, Zhou J |title=The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. |journal=Mamm. Genome |volume=11 |issue= 1 |pages= 46–50 |year= 2000 |pmid= 10602992 |doi=
*cite journal | author=Veldhuisen B, Spruit L, Dauwerse HG, "et al." |title=Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). |journal=Eur. J. Hum. Genet. |volume=7 |issue= 8 |pages= 860–72 |year= 2000 |pmid= 10602361 |doi= 10.1038/sj.ejhg.5200383
*cite journal | author=Chen XZ, Vassilev PM, Basora N, "et al." |title=Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. |journal=Nature |volume=401 |issue= 6751 |pages= 383–6 |year= 1999 |pmid= 10517637 |doi= 10.1038/43907
*cite journal | author=Tsiokas L, Arnould T, Zhu C, "et al." |title=Specific association of the gene product of PKD2 with the TRPC1 channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3934–9 |year= 1999 |pmid= 10097141 |doi=
*cite journal | author=Wu G, Hayashi T, Park JH, "et al." |title=Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. |journal=Genomics |volume=54 |issue= 3 |pages= 564–8 |year= 1999 |pmid= 9878261 |doi= 10.1006/geno.1998.5618
*cite journal | author=Nomura H, Turco AE, Pei Y, "et al." |title=Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25967–73 |year= 1998 |pmid= 9748274 |doi=PBB_Controls
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