AFAP1

Actin filament associated protein 1, also known as AFAP1, is a human gene.cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Baisden JM, Qian Y, Zot HM, Flynn DC |title=The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. |journal=Oncogene |volume=20 |issue= 44 |pages= 6435–47 |year= 2001 |pmid= 11607843 |doi= 10.1038/sj.onc.1204784
*cite journal | author=Ishida Y, Hadano S, Nagayama T, "et al." |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302–12 |year= 1995 |pmid= 7545969 |doi=
*cite journal | author=Qian Y, Baisden JM, Westin EH, "et al." |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185–95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753
*cite journal | author=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110–9 |year= 1998 |pmid= 9655255 |doi=
*cite journal | author=Qian Y, Baisden JM, Zot HG, "et al." |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102–13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795
*cite journal | author=Baisden JM, Gatesman AS, Cherezova L, "et al." |title=The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. |journal=Oncogene |volume=20 |issue= 45 |pages= 6607–16 |year= 2001 |pmid= 11641786 |doi= 10.1038/sj.onc.1204802
*cite journal | author=Qian Y, Baisden JM, Cherezova L, "et al." |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311–22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Qian Y, Gatesman AS, Baisden JM, "et al." |title=Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. |journal=J. Cell. Biochem. |volume=91 |issue= 3 |pages= 602–20 |year= 2004 |pmid= 14755689 |doi= 10.1002/jcb.10725
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Ballif BA, Villén J, Beausoleil SA, "et al." |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Dorfleutner A, Stehlik C, Zhang J, "et al." |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740–9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143

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