PRCC (gene)

Papillary renal cell carcinoma (translocation-associated), also known as PRCC, is a human gene.cite web | title = Entrez Gene: PRCC papillary renal cell carcinoma (translocation-associated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5546| accessdate = ]

PBB_Summary
section_title =
summary_text = In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to this gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect. Alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PRCC papillary renal cell carcinoma (translocation-associated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5546| accessdate = ]

External links

* http://www.arqulestudies.com Renal Cell Carninoma (translocation associated) ArQule Clinical Research Study

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zbar B, Glenn G, Lubensky I, "et al." |title=Hereditary papillary renal cell carcinoma: clinical studies in 10 families. |journal=J. Urol. |volume=153 |issue= 3 Pt 2 |pages= 907–12 |year= 1995 |pmid= 7853572 |doi=
*cite journal | author=Meloni AM, Dobbs RM, Pontes JE, Sandberg AA |title=Translocation (X;1) in papillary renal cell carcinoma. A new cytogenetic subtype. |journal=Cancer Genet. Cytogenet. |volume=65 |issue= 1 |pages= 1–6 |year= 1993 |pmid= 8431910 |doi=
*cite journal | author=Sidhar SK, Clark J, Gill S, "et al." |title=The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1333–8 |year= 1997 |pmid= 8872474 |doi=
*cite journal | author=Weterman MA, Wilbrink M, Geurts van Kessel A |title=Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15294–8 |year= 1997 |pmid= 8986805 |doi=
*cite journal | author=Weterman MJ, van Groningen JJ, Jansen A, van Kessel AG |title=Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins. |journal=Oncogene |volume=19 |issue= 1 |pages= 69–74 |year= 2000 |pmid= 10644981 |doi= 10.1038/sj.onc.1203255
*cite journal | author=Skalsky YM, Ajuh PM, Parker C, "et al." |title=PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors. |journal=Oncogene |volume=20 |issue= 2 |pages= 178–87 |year= 2001 |pmid= 11313942 |doi= 10.1038/sj.onc.1204056
*cite journal | author=Weterman MA, Wilbrink M, Eleveld M, "et al." |title=Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 326–32 |year= 2001 |pmid= 11435707 |doi=
*cite journal | author=Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG |title=Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13808–13 |year= 2002 |pmid= 11717438 |doi= 10.1073/pnas.241304198
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Anderson NL, Polanski M, Pieper R, "et al." |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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