CBY1

Chibby homolog 1 (Drosophila), also known as CBY1, is a human gene.cite web | title = Entrez Gene: CBY1 chibby homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25776| accessdate = ]

PBB_Summary
section_title =
summary_text = Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CBY1 chibby homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25776| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Suzuki Y, Tsunoda T, Sese J, "et al." |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Collins JE, Goward ME, Cole CG, "et al." |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703
*cite journal | author=Takemaru K, Yamaguchi S, Lee YS, "et al." |title=Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. |journal=Nature |volume=422 |issue= 6934 |pages= 905–9 |year= 2003 |pmid= 12712206 |doi= 10.1038/nature01570
*cite journal | author=Hidaka S, Könecke V, Osten L, Witzgall R |title=PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 35009–16 |year= 2004 |pmid= 15194699 |doi= 10.1074/jbc.M314206200
*cite journal | author=Gad S, Teboul D, Lièvre A, "et al." |title=Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ? |journal=BMC Cancer |volume=4 |issue= |pages= 31 |year= 2004 |pmid= 15245581 |doi= 10.1186/1471-2407-4-31
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schuierer MM, Graf E, Takemaru K, "et al." |title=Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines. |journal=World J. Gastroenterol. |volume=12 |issue= 10 |pages= 1529–35 |year= 2006 |pmid= 16570344 |doi=
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Li FQ, Singh AM, Mofunanya A, "et al." |title=Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=27 |issue= 12 |pages= 4347–54 |year= 2007 |pmid= 17403895 |doi= 10.1128/MCB.01640-06

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