PRC1

Protein regulator of cytokinesis 1, also known as PRC1, is a human gene.cite web | title = Entrez Gene: PRC1 protein regulator of cytokinesis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9055| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is involved in cytokinesis. The encoded protein is at high level during S and G2/M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PRC1 protein regulator of cytokinesis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9055| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jiang W, Jimenez G, Wells NJ, "et al." |title=PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 877–85 |year= 1999 |pmid= 9885575 |doi=
*cite journal | author=Mollinari C, Kleman JP, Jiang W, "et al." |title=PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. |journal=J. Cell Biol. |volume=157 |issue= 7 |pages= 1175–86 |year= 2002 |pmid= 12082078 |doi= 10.1083/jcb.200111052
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ban R, Irino Y, Fukami K, Tanaka H |title=Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16394–402 |year= 2004 |pmid= 14744859 |doi= 10.1074/jbc.M313257200
*cite journal | author=Kurasawa Y, Earnshaw WC, Mochizuki Y, "et al." |title=Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3237–48 |year= 2005 |pmid= 15297875 |doi= 10.1038/sj.emboj.7600347
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li C, Lin M, Liu J |title=Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis. |journal=Oncogene |volume=23 |issue= 58 |pages= 9336–47 |year= 2005 |pmid= 15531928 |doi= 10.1038/sj.onc.1208114
*cite journal | author=Mollinari C, Kleman JP, Saoudi Y, "et al." |title=Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. |journal=Mol. Biol. Cell |volume=16 |issue= 3 |pages= 1043–55 |year= 2005 |pmid= 15616196 |doi= 10.1091/mbc.E04-04-0346
*cite journal | author=Zhu C, Jiang W |title=Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 2 |pages= 343–8 |year= 2005 |pmid= 15625105 |doi= 10.1073/pnas.0408438102
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Zhu C, Lau E, Schwarzenbacher R, "et al." |title=Spatiotemporal control of spindle midzone formation by PRC1 in human cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 16 |pages= 6196–201 |year= 2006 |pmid= 16603632 |doi= 10.1073/pnas.0506926103
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Shimo A, Nishidate T, Ohta T, "et al." |title=Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 174–81 |year= 2007 |pmid= 17233835 |doi= 10.1111/j.1349-7006.2006.00381.x

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