SPOP

Speckle-type POZ protein, also known as SPOP, is a human gene.cite journal | author = Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M | title = Identification of a novel nuclear speckle-type protein, SPOP | journal = FEBS Lett. | volume = 418 | issue = 1-2 | pages = 23–6 | year = 1997 | month = November| pmid = 9414087 | doi = 10.1016/S0014-5793(97)01340-9 | url = | issn = ] cite journal |author = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24242–52 |year = 2001 | month = June | pmid = 11279055 | doi = 10.1074/jbc.M100354200 | url = | issn = ] cite web | title = Entrez Gene: SPOP speckle-type POZ protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405| accessdate = ]

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nagai Y, Kojima T, Muro Y, "et al." |title=Identification of a novel nuclear speckle-type protein, SPOP. |journal=FEBS Lett. |volume=418 |issue= 1-2 |pages= 23–6 |year= 1998 |pmid= 9414087 |doi=
*cite journal | author=Wu J, Song Y, Bakker AB, "et al." |title=An activating immunoreceptor complex formed by NKG2D and DAP10. |journal=Science |volume=285 |issue= 5428 |pages= 730–2 |year= 1999 |pmid= 10426994 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Zapata JM, Pawlowski K, Haas E, "et al." |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200
*cite journal | author=Takahashi I, Kameoka Y, Hashimoto K |title=MacroH2A1.2 binds the nuclear protein Spop. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 63–8 |year= 2002 |pmid= 12183056 |doi=
*cite journal | author=Gilfillan S, Ho EL, Cella M, "et al." |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150–5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857
*cite journal | author=Diefenbach A, Tomasello E, Lucas M, "et al." |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142–9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Billadeau DD, Upshaw JL, Schoon RA, "et al." |title=NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. |journal=Nat. Immunol. |volume=4 |issue= 6 |pages= 557–64 |year= 2003 |pmid= 12740575 |doi= 10.1038/ni929
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Liu A, Desai BM, Stoffers DA |title=Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 10 |pages= 4372–83 |year= 2004 |pmid= 15121856 |doi=
*cite journal | author=La M, Kim K, Park J, "et al." |title=Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 3 |pages= 760–5 |year= 2004 |pmid= 15240113 |doi= 10.1016/j.bbrc.2004.06.022
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Hernández-Muñoz I, Lund AH, van der Stoop P, "et al." |title=Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7635–40 |year= 2005 |pmid= 15897469 |doi= 10.1073/pnas.0408918102
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139

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