H2AFY

H2A histone family, member Y, also known as H2AFY, is a human gene.cite web | title = Entrez Gene: H2AFY H2A histone family, member Y| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9555| accessdate = ]

PBB_Summary
section_title =
summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: H2AFY H2A histone family, member Y| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9555| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi=
*cite journal | author=Costanzi C, Pehrson JR |title=Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. |journal=Nature |volume=393 |issue= 6685 |pages= 599–601 |year= 1998 |pmid= 9634239 |doi= 10.1038/31275
*cite journal | author=Mao M, Fu G, Wu JS, "et al." |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=
*cite journal | author=Lee Y, Hong M, Kim JW, "et al." |title=Isolation of cDNA clones encoding human histone macroH2A1 subtypes. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 73–7 |year= 1998 |pmid= 9714746 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Deng L, de la Fuente C, Fu P, "et al." |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593
*cite journal | author=Chadwick BP, Willard HF |title=Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1101–13 |year= 2001 |pmid= 11331621 |doi=
*cite journal | author=Deng L, Wang D, de la Fuente C, "et al." |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129
*cite journal | author=Chadwick BP, Willard HF |title=Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. |journal=J. Cell Biol. |volume=157 |issue= 7 |pages= 1113–23 |year= 2002 |pmid= 12082075 |doi= 10.1083/jcb.200112074
*cite journal | author=Takahashi I, Kameoka Y, Hashimoto K |title=MacroH2A1.2 binds the nuclear protein Spop. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 63–8 |year= 2002 |pmid= 12183056 |doi=
*cite journal | author=Ganesan S, Silver DP, Greenberg RA, "et al." |title=BRCA1 supports XIST RNA concentration on the inactive X chromosome. |journal=Cell |volume=111 |issue= 3 |pages= 393–405 |year= 2002 |pmid= 12419249 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Angelov D, Molla A, Perche PY, "et al." |title=The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 1033–41 |year= 2003 |pmid= 12718888 |doi=
*cite journal | author=Behrends U, Schneider I, Rössler S, "et al." |title=Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. |journal=Int. J. Cancer |volume=106 |issue= 2 |pages= 244–51 |year= 2003 |pmid= 12800201 |doi= 10.1002/ijc.11208
*cite journal | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, "et al." |title=Respiratory complex III is required to maintain complex I in mammalian mitochondria. |journal=Mol. Cell |volume=13 |issue= 6 |pages= 805–15 |year= 2004 |pmid= 15053874 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhang R, Poustovoitov MV, Ye X, "et al." |title=Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. |journal=Dev. Cell |volume=8 |issue= 1 |pages= 19–30 |year= 2005 |pmid= 15621527 |doi= 10.1016/j.devcel.2004.10.019
*cite journal | author=Hernández-Muñoz I, Lund AH, van der Stoop P, "et al." |title=Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7635–40 |year= 2005 |pmid= 15897469 |doi= 10.1073/pnas.0408918102

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