HAVCR2

Hepatitis A virus cellular receptor 2, also known as HAVCR2, is a human gene.cite web | title = Entrez Gene: HAVCR2 hepatitis A virus cellular receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84868| accessdate = ]

PBB_Summary
section_title =
summary_text = CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. [supplied by OMIM] cite web | title = Entrez Gene: HAVCR2 hepatitis A virus cellular receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84868| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Anderson DE |title=TIM-3 as a therapeutic target in human inflammatory diseases. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 8 |pages= 1005–9 |year= 2007 |pmid= 17665973 |doi= 10.1517/14728222.11.8.1005
*cite journal | author=Monney L, Sabatos CA, Gaglia JL, "et al." |title=Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. |journal=Nature |volume=415 |issue= 6871 |pages= 536–41 |year= 2002 |pmid= 11823861 |doi= 10.1038/415536a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sánchez-Fueyo A, Tian J, Picarella D, "et al." |title=Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. |journal=Nat. Immunol. |volume=4 |issue= 11 |pages= 1093–101 |year= 2003 |pmid= 14556005 |doi= 10.1038/ni987
*cite journal | author=Sabatos CA, Chakravarti S, Cha E, "et al." |title=Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. |journal=Nat. Immunol. |volume=4 |issue= 11 |pages= 1102–10 |year= 2003 |pmid= 14556006 |doi= 10.1038/ni988
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Khademi M, Illés Z, Gielen AW, "et al." |title=T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. |journal=J. Immunol. |volume=172 |issue= 11 |pages= 7169–76 |year= 2004 |pmid= 15153541 |doi=
*cite journal | author=Chae SC, Park YR, Shim SC, "et al." |title=The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis. |journal=Immunol. Lett. |volume=95 |issue= 1 |pages= 91–5 |year= 2005 |pmid= 15325803 |doi= 10.1016/j.imlet.2004.06.008
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chae SC, Park YR, Lee YC, "et al." |title=The association of TIM-3 gene polymorphism with atopic disease in Korean population. |journal=Hum. Immunol. |volume=65 |issue= 12 |pages= 1427–31 |year= 2005 |pmid= 15603868 |doi= 10.1016/j.humimm.2004.07.002
*cite journal | author=Zhu C, Anderson AC, Schubart A, "et al." |title=The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. |journal=Nat. Immunol. |volume=6 |issue= 12 |pages= 1245–52 |year= 2006 |pmid= 16286920 |doi= 10.1038/ni1271
*cite journal | author=Sui L, Zhang W, Chen Y, "et al." |title=Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells. |journal=Int. J. Mol. Med. |volume=17 |issue= 6 |pages= 1093–9 |year= 2006 |pmid= 16685421 |doi=
*cite journal | author=Koguchi K, Anderson DE, Yang L, "et al." |title=Dysregulated T cell expression of TIM3 in multiple sclerosis. |journal=J. Exp. Med. |volume=203 |issue= 6 |pages= 1413–8 |year= 2006 |pmid= 16754722 |doi= 10.1084/jem.20060210
*cite journal | author=van de Weyer PS, Muehlfeit M, Klose C, "et al." |title=A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 2 |pages= 571–6 |year= 2007 |pmid= 17069754 |doi= 10.1016/j.bbrc.2006.10.079
*cite journal | author=Wiener Z, Kohalmi B, Pocza P, "et al." |title=TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells. |journal=J. Invest. Dermatol. |volume=127 |issue= 4 |pages= 906–14 |year= 2007 |pmid= 17096021 |doi= 10.1038/sj.jid.5700616
*cite journal | author=Renesto PG, Ponciano VC, Cenedeze MA, "et al." |title=High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection. |journal=Am. J. Transplant. |volume=7 |issue= 6 |pages= 1661–5 |year= 2007 |pmid= 17430399 |doi= 10.1111/j.1600-6143.2007.01795.x
*cite journal | author=Anderson AC, Anderson DE, Bregoli L, "et al." |title=Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. |journal=Science |volume=318 |issue= 5853 |pages= 1141–3 |year= 2007 |pmid= 18006747 |doi= 10.1126/science.1148536

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