CCBL1

Cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), also known as CCBL1, is a human gene.cite web | title = Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=883| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.cite web | title = Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=883| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cooper AJ |title=The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. |journal=Neurochem. Int. |volume=44 |issue= 8 |pages= 557–77 |year= 2004 |pmid= 15016471 |doi= 10.1016/j.neuint.2003.12.002
*cite journal | author=Lash LH, Nelson RM, Van Dyke RA, Anders MW |title=Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity. |journal=Drug Metab. Dispos. |volume=18 |issue= 1 |pages= 50–4 |year= 1990 |pmid= 2139845 |doi=
*cite journal | author=Abraham DG, Patel PP, Cooper AJ |title=Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4. |journal=J. Biol. Chem. |volume=270 |issue= 1 |pages= 180–8 |year= 1995 |pmid= 7814371 |doi=
*cite journal | author=Perry S, Harries H, Scholfield C, "et al." |title=Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase. |journal=FEBS Lett. |volume=360 |issue= 3 |pages= 277–80 |year= 1995 |pmid= 7883047 |doi=
*cite journal | author=Goldfarb P, Perry S, Harries H, "et al." |title=Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase. |journal=Biochem. Soc. Trans. |volume=24 |issue= 2 |pages= 330S |year= 1996 |pmid= 8736988 |doi=
*cite journal | author=Iyer RA, Anders MW |title=Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria. |journal=Anesthesiology |volume=85 |issue= 6 |pages= 1454–61 |year= 1997 |pmid= 8968194 |doi=
*cite journal | author=Gilley J, Fried M |title=Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. |journal=Hum. Mol. Genet. |volume=8 |issue= 7 |pages= 1313–20 |year= 1999 |pmid= 10369878 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Kapoor R, Lim KS, Cheng A, "et al." |title=Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). |journal=Brain Res. |volume=1106 |issue= 1 |pages= 205–10 |year= 2006 |pmid= 16828464 |doi= 10.1016/j.brainres.2006.05.082

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