PRDM16

PR domain containing 16, also known as PRDM16, is a human gene.cite web | title = Entrez Gene: PRDM16 PR domain containing 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63976| accessdate = ]

PBB_Summary
section_title =
summary_text = The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: PRDM16 PR domain containing 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63976| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Bloomfield CD, Garson OM, Volin L, "et al." |title=t(1;3)(p36;q21) in acute nonlymphocytic leukemia: a new cytogenetic-clinicopathologic association. |journal=Blood |volume=66 |issue= 6 |pages= 1409–13 |year= 1986 |pmid= 4063527 |doi=
*cite journal | author=Secker-Walker LM, Mehta A, Bain B |title=Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study. |journal=Br. J. Haematol. |volume=91 |issue= 2 |pages= 490–501 |year= 1996 |pmid= 8547101 |doi=
*cite journal | author=Mochizuki N, Shimizu S, Nagasawa T, "et al." |title=A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. |journal=Blood |volume=96 |issue= 9 |pages= 3209–14 |year= 2000 |pmid= 11050005 |doi=
*cite journal | author=Nagase T, Kikuno R, Hattori A, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xinh PT, Tri NK, Nagao H, "et al." |title=Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1. |journal=Genes Chromosomes Cancer |volume=36 |issue= 3 |pages= 313–6 |year= 2003 |pmid= 12557231 |doi= 10.1002/gcc.10176
*cite journal | author=Nishikata I, Sasaki H, Iga M, "et al." |title=A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. |journal=Blood |volume=102 |issue= 9 |pages= 3323–32 |year= 2004 |pmid= 12816872 |doi= 10.1182/blood-2002-12-3944
*cite journal | author=Yoshida M, Nosaka K, Yasunaga J, "et al." |title=Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. |journal=Blood |volume=103 |issue= 7 |pages= 2753–60 |year= 2004 |pmid= 14656887 |doi= 10.1182/blood-2003-07-2482
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lahortiga I, Agirre X, Belloni E, "et al." |title=Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 311–6 |year= 2004 |pmid= 14712237 |doi= 10.1038/sj.onc.1206923
*cite journal | author=Ott MG, Schmidt M, Schwarzwaelder K, "et al." |title=Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. |journal=Nat. Med. |volume=12 |issue= 4 |pages= 401–9 |year= 2006 |pmid= 16582916 |doi= 10.1038/nm1393
*cite journal | author=Stevens-Kroef MJ, Schoenmakers EF, van Kraaij M, "et al." |title=Identification of truncated RUNX1 and RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive therapy-related AML. |journal=Leukemia |volume=20 |issue= 6 |pages= 1187–9 |year= 2006 |pmid= 16598304 |doi= 10.1038/sj.leu.2404210
*cite journal | author=Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G |title=Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. |journal=J. Am. Chem. Soc. |volume=128 |issue= 17 |pages= 5913–22 |year= 2007 |pmid= 16637659 |doi= 10.1021/ja060943h

External links

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