THBS4

Thrombospondin 4, also known as THBS4, is a human gene.cite web | title = Entrez Gene: THBS4 thrombospondin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7060| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.cite web | title = Entrez Gene: THBS4 thrombospondin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7060| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Arber S, Caroni P |title=Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. |journal=J. Cell Biol. |volume=131 |issue= 4 |pages= 1083–94 |year= 1996 |pmid= 7490284 |doi=
*cite journal | author=Lawler J, McHenry K, Duquette M, Derick L |title=Characterization of human thrombospondin-4. |journal=J. Biol. Chem. |volume=270 |issue= 6 |pages= 2809–14 |year= 1995 |pmid= 7852353 |doi=
*cite journal | author=Lawler J, Duquette M, Urry L, "et al." |title=The evolution of the thrombospondin gene family. |journal=J. Mol. Evol. |volume=36 |issue= 6 |pages= 509–16 |year= 1993 |pmid= 8350346 |doi=
*cite journal | author=Lawler J, Duquette M, Whittaker CA, "et al." |title=Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. |journal=J. Cell Biol. |volume=120 |issue= 4 |pages= 1059–67 |year= 1993 |pmid= 8432726 |doi=
*cite journal | author=Newton G, Weremowicz S, Morton CC, "et al." |title=The thrombospondin-4 gene. |journal=Mamm. Genome |volume=10 |issue= 10 |pages= 1010–6 |year= 2000 |pmid= 10501972 |doi=
*cite journal | author=Carron JA, Hiscott P, Hagan S, "et al." |title=Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 11-12 |pages= 1137–42 |year= 2001 |pmid= 11137453 |doi=
*cite journal | author=Luo J, Dunn T, Ewing C, "et al." |title=Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis. |journal=Prostate |volume=51 |issue= 3 |pages= 189–200 |year= 2002 |pmid= 11967953 |doi= 10.1002/pros.10087
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Congote LF, Difalco MR, Gibbs BF |title=The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 2 |pages= 673–8 |year= 2004 |pmid= 15474480 |doi= 10.1016/j.bbrc.2004.09.107
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=van Doorn R, Zoutman WH, Dijkman R, "et al." |title=Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. |journal=J. Clin. Oncol. |volume=23 |issue= 17 |pages= 3886–96 |year= 2005 |pmid= 15897551 |doi= 10.1200/JCO.2005.11.353
*cite journal | author=Stenina OI, Ustinov V, Krukovets I, "et al." |title=Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites. |journal=FASEB J. |volume=19 |issue= 13 |pages= 1893–5 |year= 2006 |pmid= 16148025 |doi= 10.1096/fj.05-3712fje
*cite journal | author=Misenheimer TM, Mosher DF |title=Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41229–35 |year= 2006 |pmid= 16246837 |doi= 10.1074/jbc.M504696200
*cite journal | author=Cui J, Randell E, Renouf J, "et al." |title=Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. |journal=Am. Heart J. |volume=152 |issue= 3 |pages= 543.e1–5 |year= 2006 |pmid= 16923428 |doi= 10.1016/j.ahj.2006.06.002
*cite journal | author=Cáceres M, Suwyn C, Maddox M, "et al." |title=Increased cortical expression of two synaptogenic thrombospondins in human brain evolution. |journal=Cereb. Cortex |volume=17 |issue= 10 |pages= 2312–21 |year= 2007 |pmid= 17182969 |doi= 10.1093/cercor/bhl140

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