AURKC

Aurora kinase C, also known as AURKC, is a human gene.cite web | title = Entrez Gene: AURKC aurora kinase C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6795| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.cite web | title = Entrez Gene: AURKC aurora kinase C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6795| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Katayama H, Brinkley WR, Sen S |title=The Aurora kinases: role in cell transformation and tumorigenesis. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 451–64 |year= 2004 |pmid= 12884918 |doi=
*cite journal | author=Bernard M, Sanseau P, Henry C, "et al." |title=Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. |journal=Genomics |volume=53 |issue= 3 |pages= 406–9 |year= 1998 |pmid= 9799611 |doi= 10.1006/geno.1998.5522
*cite journal | author=Tseng TC, Chen SH, Hsu YP, Tang TK |title=Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. |journal=DNA Cell Biol. |volume=17 |issue= 10 |pages= 823–33 |year= 1998 |pmid= 9809744 |doi=
*cite journal | author=Kimura M, Matsuda Y, Yoshioka T, Okano Y |title=Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7334–40 |year= 1999 |pmid= 10066797 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark AG, Glanowski S, Nielsen R, "et al." |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Li X, Sakashita G, Matsuzaki H, "et al." |title=Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47201–11 |year= 2004 |pmid= 15316025 |doi= 10.1074/jbc.M403029200
*cite journal | author=Sasai K, Katayama H, Stenoien DL, "et al." |title=Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. |journal=Cell Motil. Cytoskeleton |volume=59 |issue= 4 |pages= 249–63 |year= 2005 |pmid= 15499654 |doi= 10.1002/cm.20039
*cite journal | author=Yan X, Wu Y, Li Q, "et al." |title=Cloning and characterization of a novel human Aurora C splicing variant. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 353–61 |year= 2005 |pmid= 15670791 |doi= 10.1016/j.bbrc.2004.12.168
*cite journal | author=Chen HL, Tang CJ, Chen CY, Tang TK |title=Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. |journal=J. Biomed. Sci. |volume=12 |issue= 2 |pages= 297–310 |year= 2005 |pmid= 15917996 |doi= 10.1007/s11373-005-0980-0
*cite journal | author=Yan X, Cao L, Li Q, "et al." |title=Aurora C is directly associated with Survivin and required for cytokinesis. |journal=Genes Cells |volume=10 |issue= 6 |pages= 617–26 |year= 2005 |pmid= 15938719 |doi= 10.1111/j.1365-2443.2005.00863.x
*cite journal | author=Dutertre S, Hamard-Péron E, Cremet JY, "et al." |title=The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. |journal=Cell Cycle |volume=4 |issue= 12 |pages= 1783–7 |year= 2006 |pmid= 16258285 |doi=
*cite journal | author=Dieterich K, Soto Rifo R, Faure AK, "et al." |title=Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. |journal=Nat. Genet. |volume=39 |issue= 5 |pages= 661–5 |year= |pmid= 17435757 |doi= 10.1038/ng2027

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