UBQLN2

Ubiquilin 2, also known as UBQLN2, is a human gene.cite web | title = Entrez Gene: UBQLN2 ubiquilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29978| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.cite web | title = Entrez Gene: UBQLN2 ubiquilin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29978| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ueki N, Oda T, Kondo M, "et al." |title=Selection system for genes encoding nuclear-targeted proteins. |journal=Nat. Biotechnol. |volume=16 |issue= 13 |pages= 1338–42 |year= 1999 |pmid= 9853615 |doi= 10.1038/4315
*cite journal | author=Kaye FJ, Modi S, Ivanovska I, "et al." |title=A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. |journal=FEBS Lett. |volume=467 |issue= 2-3 |pages= 348–55 |year= 2000 |pmid= 10675567 |doi=
*cite journal | author=Kaye FJ, Shows TB |title=Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 116–7 |year= 2000 |pmid= 10894951 |doi=
*cite journal | author=Kleijnen MF, Shih AH, Zhou P, "et al." |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=
*cite journal | author=Murillas R, Simms KS, Hatakeyama S, "et al." |title=Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2897–907 |year= 2002 |pmid= 11717310 |doi= 10.1074/jbc.M110047200
*cite journal | author=Walters KJ, Kleijnen MF, Goh AM, "et al." |title=Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. |journal=Biochemistry |volume=41 |issue= 6 |pages= 1767–77 |year= 2002 |pmid= 11827521 |doi=
*cite journal | author=Saeki Y, Sone T, Toh-e A, Yokosawa H |title=Identification of ubiquitin-like protein-binding subunits of the 26S proteasome. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 4 |pages= 813–9 |year= 2002 |pmid= 12200120 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kleijnen MF, Alarcon RM, Howley PM |title=The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome. |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3868–75 |year= 2004 |pmid= 12972570 |doi= 10.1091/mbc.E02-11-0766
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Massey LK, Mah AL, Monteiro MJ |title=Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin. |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 513–25 |year= 2006 |pmid= 15975090 |doi= 10.1042/BJ20050491
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Ford DL, Monteiro MJ |title=Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins. |journal=Biochem. J. |volume=399 |issue= 3 |pages= 397–404 |year= 2006 |pmid= 16813565 |doi= 10.1042/BJ20060441
*cite journal | author=Kang Y, Zhang N, Koepp DM, Walters KJ |title=Ubiquitin receptor proteins hHR23a and hPLIC2 interact. |journal=J. Mol. Biol. |volume=365 |issue= 4 |pages= 1093–101 |year= 2007 |pmid= 17098253 |doi= 10.1016/j.jmb.2006.10.056

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