Cas-Br-M (murine) ecotropic retroviral transforming sequence c, also known as CBLC, is a human gene.cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = ]

section_title =
summary_text = CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999). [supplied by OMIM] cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = ]


Further reading

citations =
*cite journal | author=Ollendorff V, Mattei M, Fournier E, "et al." |title=A third human CBL gene is on chromosome 19 |journal=Int. J. Oncol. |volume=13 |issue= 6 |pages= 1159–61 |year= 1999 |pmid= 9824625 |doi=
*cite journal | author=Irby RB, Mao W, Coppola D, "et al." |title=Activating SRC mutation in a subset of advanced human colon cancers |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 187–90 |year= 1999 |pmid= 9988270 |doi= 10.1038/5971
*cite journal | author=Ettenberg SA, Keane MM, Nau MM, "et al." |title=Cbl-b inhibits epidermal growth factor receptor signaling |journal=Oncogene |volume=18 |issue= 10 |pages= 1855–66 |year= 1999 |pmid= 10086340 |doi= 10.1038/sj.onc.1202499
*cite journal | author=Keane MM, Ettenberg SA, Nau MM, "et al." |title=Cbl-3: a new mammalian cbl family protein |journal=Oncogene |volume=18 |issue= 22 |pages= 3365–75 |year= 1999 |pmid= 10362357 |doi= 10.1038/sj.onc.1202753
*cite journal | author=Kim M, Tezuka T, Suziki Y, "et al." |title=Molecular cloning and characterization of a novel cbl-family gene, cbl-c |journal=Gene |volume=239 |issue= 1 |pages= 145–54 |year= 1999 |pmid= 10571044 |doi=
*cite journal | author=Loreto MP, Berry DM, McGlade CJ |title=Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4241–55 |year= 2002 |pmid= 12024036 |doi=
*cite journal | author=Szymkiewicz I, Kowanetz K, Soubeyran P, "et al." |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200
*cite journal | author=Courbard JR, Fiore F, Adélaïde J, "et al." |title=Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45267–75 |year= 2003 |pmid= 12226085 |doi= 10.1074/jbc.M206460200
*cite journal | author=Wong ES, Fong CW, Lim J, "et al." |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling |journal=Embo J. |volume=21 |issue= 18 |pages= 4796–808 |year= 2002 |pmid= 12234920 |doi=
*cite journal | author=Taher TE, Tjin EP, Beuling EA, "et al." |title=C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3793–800 |year= 2002 |pmid= 12244174 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nau MM, Lipkowitz S |title=Comparative genomic organization of the cbl genes |journal=Gene |volume=308 |issue= |pages= 103–13 |year= 2003 |pmid= 12711395 |doi=
*cite journal | author=Kim M, Tezuka T, Tanaka K, Yamamoto T |title=Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation |journal=Oncogene |volume=23 |issue= 9 |pages= 1645–55 |year= 2004 |pmid= 14661060 |doi= 10.1038/sj.onc.1207298
*cite journal | author=Kassenbrock CK, Anderson SM |title=Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28017–27 |year= 2004 |pmid= 15117950 |doi= 10.1074/jbc.M404114200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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