Phosducin family

Pfam_box
Symbol = Phosducin
Name =

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width =250
caption =Phosducin (yellow) - Transducin beta-gamma complex
Pfam= PF02114
InterPro= IPR001200
SMART=
Prosite =
SCOP = 1b9y
TCDB =
OPM family=139
OPM protein= 1b9x
PDB=PDB3|1b9xC:39-246 PDB3|2trcP:14-230 PDB3|1b9yC:1-246

The outer and inner segments of vertebrate rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase Acite journal |author=Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF |title=Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells |journal=J. Biol. Chem. |volume=265 |issue=26 |pages=15867–15873 |year=1990 |pmid=2203790] . The protein is thought to participate in the regulation of visual phototransduction or in the integration of photo-receptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the functional role of the protein is the same in both retina and pineal glandcite journal |author=Takagi T, Abe T, Nakabayashi H, Tamada H, Sakuragi S, Yamaki K, Shinohara T |title=Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland |journal=Gene |volume=91 |issue=2 |pages=209–215 |year=1990 |pmid=2210381 |doi=10.1016/0378-1119(90)90090-E] .

Human proteins containing this domain

PDC; PDCL2; PDCL3; VIAF1;

References