IRS4

Insulin receptor substrate 4, also known as IRS4, is a human gene.cite web | title = Entrez Gene: IRS4 insulin receptor substrate 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8471| accessdate = ]

PBB_Summary
section_title =
summary_text = IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..cite web | title = Entrez Gene: IRS4 insulin receptor substrate 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8471| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=White MF |title=The IRS-signalling system: a network of docking proteins that mediate insulin action. |journal=Mol. Cell. Biochem. |volume=182 |issue= 1-2 |pages= 3–11 |year= 1999 |pmid= 9609109 |doi=
*cite journal | author=Lavan BE, Fantin VR, Chang ET, "et al." |title=A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21403–7 |year= 1997 |pmid= 9261155 |doi=
*cite journal | author=Fantin VR, Sparling JD, Slot JW, "et al." |title=Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10726–32 |year= 1998 |pmid= 9553137 |doi=
*cite journal | author=Koval AP, Karas M, Zick Y, LeRoith D |title=Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 14780–7 |year= 1998 |pmid= 9614078 |doi=
*cite journal | author=Uchida T, Myers MG, White MF |title=IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. |journal=Mol. Cell. Biol. |volume=20 |issue= 1 |pages= 126–38 |year= 2000 |pmid= 10594015 |doi=
*cite journal | author=Karas M, Koval AP, Zick Y, LeRoith D |title=The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. |journal=Endocrinology |volume=142 |issue= 5 |pages= 1835–40 |year= 2001 |pmid= 11316748 |doi=
*cite journal | author=Sano H, Liu SC, Lane WS, "et al." |title=Insulin receptor substrate 4 associates with the protein IRAS. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19439–47 |year= 2002 |pmid= 11912194 |doi= 10.1074/jbc.M111838200
*cite journal | author=Krebs DL, Uren RT, Metcalf D, "et al." |title=SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4567–78 |year= 2002 |pmid= 12052866 |doi=
*cite journal | author=Schreyer S, Ledwig D, Rakatzi I, "et al." |title=Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor. |journal=Endocrinology |volume=144 |issue= 4 |pages= 1211–8 |year= 2003 |pmid= 12639902 |doi=
*cite journal | author=Escribano O, Fernández-Moreno MD, Zueco JA, "et al." |title=Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver. |journal=Hepatology |volume=37 |issue= 6 |pages= 1461–9 |year= 2003 |pmid= 12774026 |doi= 10.1053/jhep.2003.50245
*cite journal | author=Yen HW, Jakimiuk AJ, Munir I, Magoffin DA |title=Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries. |journal=Mol. Hum. Reprod. |volume=10 |issue= 7 |pages= 473–9 |year= 2005 |pmid= 15155816 |doi= 10.1093/molehr/gah066
*cite journal | author=Hinsby AM, Olsen JV, Mann M |title=Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46438–47 |year= 2004 |pmid= 15316024 |doi= 10.1074/jbc.M404537200
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Mihindukulasuriya KA, Zhou G, Qin J, Tan TH |title=Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46588–94 |year= 2004 |pmid= 15331607 |doi= 10.1074/jbc.M408067200
*cite journal | author=Qiu H, Zappacosta F, Su W, "et al." |title=Interaction between Brk kinase and insulin receptor substrate-4. |journal=Oncogene |volume=24 |issue= 36 |pages= 5656–64 |year= 2005 |pmid= 15870689 |doi= 10.1038/sj.onc.1208721
*cite journal | author=Cuevas EP, Escribano O, Chiloeches A, "et al." |title=Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation. |journal=J. Hepatol. |volume=46 |issue= 6 |pages= 1089–98 |year= 2007 |pmid= 17408801 |doi= 10.1016/j.jhep.2007.01.031

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