PFKFB2

PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, also known as PFKFB2, is a human gene.cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rider MH, Vandamme J, Lebeau E, "et al." |title=The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. |journal=Biochem. J. |volume=285 ( Pt 2) |issue= |pages= 405–11 |year= 1992 |pmid= 1322130 |doi=
*cite journal | author=Hilliker CE, Darville MI, Aly MS, "et al." |title=Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. |journal=Genomics |volume=10 |issue= 4 |pages= 867–73 |year= 1991 |pmid= 1655632 |doi=
*cite journal | author=Goldmuntz EA, Remmers EF, Zha H, "et al." |title=Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5. |journal=Mamm. Genome |volume=4 |issue= 11 |pages= 670–5 |year= 1994 |pmid= 7904197 |doi=
*cite journal | author=Hirata T, Kato M, Okamura N, "et al." |title=Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 680–4 |year= 1998 |pmid= 9464277 |doi= 10.1006/bbrc.1997.8024
*cite journal | author=Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S |title=Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). |journal=Eur. J. Biochem. |volume=254 |issue= 1 |pages= 103–10 |year= 1998 |pmid= 9652401 |doi=
*cite journal | author=Hirata T, Watanabe M, Miura S, "et al." |title=Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues. |journal=Biosci. Biotechnol. Biochem. |volume=64 |issue= 10 |pages= 2047–52 |year= 2001 |pmid= 11129574 |doi=
*cite journal | author=Kessler R, Eschrich K |title=Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 190–5 |year= 2001 |pmid= 11245921 |doi=
*cite journal | author=Soejima H, Kawamoto S, Akai J, "et al." |title=Isolation of novel heart-specific genes using the BodyMap database. |journal=Genomics |volume=74 |issue= 1 |pages= 115–20 |year= 2001 |pmid= 11374908 |doi= 10.1006/geno.2001.6527
*cite journal | author=Baltrusch S, Lenzen S, Okar DA, "et al." |title=Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43915–23 |year= 2001 |pmid= 11522786 |doi= 10.1074/jbc.M105470200
*cite journal | author=Marsin AS, Bouzin C, Bertrand L, Hue L |title=The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30778–83 |year= 2002 |pmid= 12065600 |doi= 10.1074/jbc.M205213200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pozuelo Rubio M, Peggie M, Wong BH, "et al." |title=14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3514–23 |year= 2003 |pmid= 12853467 |doi= 10.1093/emboj/cdg363
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • PFKFB — Phosphofructokinase 2/ Fructose 2,6 bisphosphatase Bänder /Oberflächenmodell des Dimer. Die PF …   Deutsch Wikipedia

  • Phosphofructokinase 2 — Phosphofructokinase 2/ Fructose 2,6 bisphosphatase Bänder /Oberflächenmodell des Dimer. Die PFK Domäne ist blau, die FB Domän …   Deutsch Wikipedia

  • Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia

  • Gluconeogenesis — Not to be confused with Glycogenesis or Glyceroneogenesis. Gluconeogenesis pathway with key molecules and enzymes. Many steps are the opposite of those found in the glycolysis. Gluconeogenesis (abbreviated GNG) is a metabolic pathway that… …   Wikipedia

  • Glucokinase — (hexokinase 4) Based on PDB entry 1GLK …   Wikipedia

  • Cori cycle — The Cori cycle (also known as Lactic acid cycle), named after its discoverers, Carl Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to… …   Wikipedia

  • Phosphofructokinase 2 — (PFK2) is one activity of a bifunctional enzyme (EC number|2.7.1.105), the other of which is fructose 2,6 bisphosphatase (FBPase2). When serine 32 is phosphorylated, the negative charge causes the conformation of the enzyme to favor the FBPase2… …   Wikipedia

  • Phosphoenolpyruvate carboxykinase — Not to be confused with Phosphoenolpyruvate carboxylase. Phosphoenolpyruvate carboxykinase PDB rendering based on 1khb. Identifiers Symbol …   Wikipedia

  • Fructose 2,6-bisphosphatase — is an enzyme that catalyzes the following reaction: fructose 2,6 bisphosphate + H2O > fructose 6 phosphate + phosphate ionFructose 2,6 bisphosphatase is important in regulation of gluconeogenesis glycolysis as it catalyzes the dephosphorylation… …   Wikipedia

  • Phosphofructokinase — PFK redirects here. PFK (Poulet Frit Kentucky) is also the name for KFC in French speaking Quebec, Canada. For the Polish hip hop group, see Paktofonika. Phosphofructokinase Identifiers Symbol Ppfruckinase Pfam …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”