PFKFB2

PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, also known as PFKFB2, is a human gene.cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rider MH, Vandamme J, Lebeau E, "et al." |title=The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. |journal=Biochem. J. |volume=285 ( Pt 2) |issue= |pages= 405–11 |year= 1992 |pmid= 1322130 |doi=
*cite journal | author=Hilliker CE, Darville MI, Aly MS, "et al." |title=Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. |journal=Genomics |volume=10 |issue= 4 |pages= 867–73 |year= 1991 |pmid= 1655632 |doi=
*cite journal | author=Goldmuntz EA, Remmers EF, Zha H, "et al." |title=Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5. |journal=Mamm. Genome |volume=4 |issue= 11 |pages= 670–5 |year= 1994 |pmid= 7904197 |doi=
*cite journal | author=Hirata T, Kato M, Okamura N, "et al." |title=Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 680–4 |year= 1998 |pmid= 9464277 |doi= 10.1006/bbrc.1997.8024
*cite journal | author=Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S |title=Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). |journal=Eur. J. Biochem. |volume=254 |issue= 1 |pages= 103–10 |year= 1998 |pmid= 9652401 |doi=
*cite journal | author=Hirata T, Watanabe M, Miura S, "et al." |title=Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues. |journal=Biosci. Biotechnol. Biochem. |volume=64 |issue= 10 |pages= 2047–52 |year= 2001 |pmid= 11129574 |doi=
*cite journal | author=Kessler R, Eschrich K |title=Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 190–5 |year= 2001 |pmid= 11245921 |doi=
*cite journal | author=Soejima H, Kawamoto S, Akai J, "et al." |title=Isolation of novel heart-specific genes using the BodyMap database. |journal=Genomics |volume=74 |issue= 1 |pages= 115–20 |year= 2001 |pmid= 11374908 |doi= 10.1006/geno.2001.6527
*cite journal | author=Baltrusch S, Lenzen S, Okar DA, "et al." |title=Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43915–23 |year= 2001 |pmid= 11522786 |doi= 10.1074/jbc.M105470200
*cite journal | author=Marsin AS, Bouzin C, Bertrand L, Hue L |title=The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30778–83 |year= 2002 |pmid= 12065600 |doi= 10.1074/jbc.M205213200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pozuelo Rubio M, Peggie M, Wong BH, "et al." |title=14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3514–23 |year= 2003 |pmid= 12853467 |doi= 10.1093/emboj/cdg363
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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