MGAT3

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, also known as MGAT3, is a human gene.cite web | title = Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4248| accessdate = ]

PBB_Summary
section_title =
summary_text = There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.cite web | title = Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4248| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ihara Y, Nishikawa A, Tohma T, "et al." |title=cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III). |journal=J. Biochem. |volume=113 |issue= 6 |pages= 692–8 |year= 1993 |pmid= 8370666 |doi=
*cite journal | author=Kim YJ, Park JH, Kim KS, "et al." |title=Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III. |journal=Gene |volume=170 |issue= 2 |pages= 281–3 |year= 1996 |pmid= 8666260 |doi=
*cite journal | author=Koyama N, Miyoshi E, Ihara Y, "et al." |title=Human N-acetylglucosaminyltransferase III gene is transcribed from multiple promoters. |journal=Eur. J. Biochem. |volume=238 |issue= 3 |pages= 853–61 |year= 1996 |pmid= 8706690 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Ikeda Y, Koyota S, Ihara H, "et al." |title=Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III. |journal=J. Biochem. |volume=128 |issue= 4 |pages= 609–19 |year= 2000 |pmid= 11011143 |doi=
*cite journal | author=Song EY, Kang SK, Lee YC, "et al." |title=Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2. |journal=Cancer Invest. |volume=19 |issue= 8 |pages= 799–807 |year= 2002 |pmid= 11768033 |doi=
*cite journal | author=Shibukawa Y, Takahashi M, Laffont I, "et al." |title=Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3197–203 |year= 2003 |pmid= 12427758 |doi= 10.1074/jbc.M207870200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sasai K, Ikeda Y, Ihara H, "et al." |title=Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25295–301 |year= 2003 |pmid= 12716887 |doi= 10.1074/jbc.M301913200
*cite journal | author=Millar JK, Christie S, Porteous DJ |title=Yeast two-hybrid screens implicate DISC1 in brain development and function. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 4 |pages= 1019–25 |year= 2004 |pmid= 14623284 |doi=
*cite journal | author=Isaji T, Gu J, Nishiuchi R, "et al." |title=Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 19747–54 |year= 2004 |pmid= 14998999 |doi= 10.1074/jbc.M311627200
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Fiala M, Liu PT, Espinosa-Jeffrey A, "et al." |title=Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 31 |pages= 12849–54 |year= 2007 |pmid= 17652175 |doi= 10.1073/pnas.0701267104

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