LOXL2

Lysyl oxidase-like 2, also known as LOXL2, is a human gene.cite web | title = Entrez Gene: LOXL2 lysyl oxidase-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4017| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.cite web | title = Entrez Gene: LOXL2 lysyl oxidase-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4017| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Csiszar K |title=Lysyl oxidases: a novel multifunctional amine oxidase family. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=70 |issue= |pages= 1–32 |year= 2001 |pmid= 11642359 |doi=
*cite journal | author=Molnar J, Fong KS, He QP, "et al." |title=Structural and functional diversity of lysyl oxidase and the LOX-like proteins. |journal=Biochim. Biophys. Acta |volume=1647 |issue= 1-2 |pages= 220–4 |year= 2003 |pmid= 12686136 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Saito H, Papaconstantinou J, Sato H, Goldstein S |title=Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8157–60 |year= 1997 |pmid= 9079631 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Jourdan-Le Saux C, Le Saux O, Donlon T, "et al." |title=The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. |journal=Genomics |volume=51 |issue= 2 |pages= 305–7 |year= 1998 |pmid= 9722957 |doi= 10.1006/geno.1998.5356
*cite journal | author=Jourdan-Le Saux C, Tronecker H, Bogic L, "et al." |title=The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12939–44 |year= 1999 |pmid= 10212285 |doi=
*cite journal | author=Hein S, Yamamoto SY, Okazaki K, "et al." |title=Lysyl oxidases: expression in the fetal membranes and placenta. |journal=Placenta |volume=22 |issue= 1 |pages= 49–57 |year= 2001 |pmid= 11162352 |doi= 10.1053/plac.2000.0580
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Akiri G, Sabo E, Dafni H, "et al." |title=Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo. |journal=Cancer Res. |volume=63 |issue= 7 |pages= 1657–66 |year= 2003 |pmid= 12670920 |doi=
*cite journal | author=Rost T, Pyritz V, Rathcke IO, "et al." |title=Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas. |journal=Anticancer Res. |volume=23 |issue= 2B |pages= 1565–73 |year= 2003 |pmid= 12820424 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vadasz Z, Kessler O, Akiri G, "et al." |title=Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. |journal=J. Hepatol. |volume=43 |issue= 3 |pages= 499–507 |year= 2005 |pmid= 16023247 |doi= 10.1016/j.jhep.2005.02.052
*cite journal | author=Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, "et al." |title=A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. |journal=EMBO J. |volume=24 |issue= 19 |pages= 3446–58 |year= 2006 |pmid= 16096638 |doi= 10.1038/sj.emboj.7600781
*cite journal | author=Akagawa H, Narita A, Yamada H, "et al." |title=Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 377–87 |year= 2007 |pmid= 17287949 |doi= 10.1007/s00439-007-0333-3

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