LOXL3

Lysyl oxidase-like 3, also known as LOXL3, is a human gene.cite web | title = Entrez Gene: LOXL3 lysyl oxidase-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84695| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.cite web | title = Entrez Gene: LOXL3 lysyl oxidase-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84695| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Molnar J, Fong KS, He QP, "et al." |title=Structural and functional diversity of lysyl oxidase and the LOX-like proteins. |journal=Biochim. Biophys. Acta |volume=1647 |issue= 1-2 |pages= 220-4 |year= 2003 |pmid= 12686136 |doi=
*cite journal | author=Csiszar K |title=Lysyl oxidases: a novel multifunctional amine oxidase family. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=70 |issue= |pages= 1-32 |year= 2001 |pmid= 11642359 |doi=
*cite journal | author=Akagawa H, Narita A, Yamada H, "et al." |title=Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 377-87 |year= 2007 |pmid= 17287949 |doi= 10.1007/s00439-007-0333-3
*cite journal | author=Lee JE, Kim Y |title=A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity. |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 37282-90 |year= 2007 |pmid= 17018530 |doi= 10.1074/jbc.M600977200
*cite journal | author=Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, "et al." |title=A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. |journal=EMBO J. |volume=24 |issue= 19 |pages= 3446-58 |year= 2006 |pmid= 16096638 |doi= 10.1038/sj.emboj.7600781
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jourdan-Le Saux C, Tomsche A, Ujfalusi A, "et al." |title=Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. |journal=Genomics |volume=74 |issue= 2 |pages= 211-8 |year= 2001 |pmid= 11386757 |doi= 10.1006/geno.2001.6545
*cite journal | author=Huang Y, Dai J, Tang R, "et al." |title=Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3). |journal=Matrix Biol. |volume=20 |issue= 2 |pages= 153-7 |year= 2001 |pmid= 11334717 |doi=
*cite journal | author=Mäki JM, Kivirikko KI |title=Cloning and characterization of a fourth human lysyl oxidase isoenzyme. |journal=Biochem. J. |volume=355 |issue= Pt 2 |pages= 381-7 |year= 2001 |pmid= 11284725 |doi=

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