RABGEF1

RAB guanine nucleotide exchange factor (GEF) 1, also known as RABGEF1, is a human gene.cite web | title = Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27342| accessdate = ]

PBB_Summary
section_title =
summary_text = RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997). [supplied by OMIM] cite web | title = Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27342| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Horiuchi H, Lippé R, McBride HM, "et al." |title=A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. |journal=Cell |volume=90 |issue= 6 |pages= 1149–59 |year= 1997 |pmid= 9323142 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nimmrich I, Erdmann S, Melchers U, "et al." |title=Seven genes that are differentially transcribed in colorectal tumor cell lines. |journal=Cancer Lett. |volume=160 |issue= 1 |pages= 37–43 |year= 2000 |pmid= 11098082 |doi=
*cite journal | author=Lippé R, Miaczynska M, Rybin V, "et al." |title=Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. |journal=Mol. Biol. Cell |volume=12 |issue= 7 |pages= 2219–28 |year= 2001 |pmid= 11452015 |doi=
*cite journal | author=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124–33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mattera R, Arighi CN, Lodge R, "et al." |title=Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. |journal=EMBO J. |volume=22 |issue= 1 |pages= 78–88 |year= 2003 |pmid= 12505986 |doi= 10.1093/emboj/cdg015
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Delprato A, Merithew E, Lambright DG |title=Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. |journal=Cell |volume=118 |issue= 5 |pages= 607–17 |year= 2004 |pmid= 15339665 |doi= 10.1016/j.cell.2004.08.009
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Penengo L, Mapelli M, Murachelli AG, "et al." |title=Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. |journal=Cell |volume=124 |issue= 6 |pages= 1183–95 |year= 2006 |pmid= 16499958 |doi= 10.1016/j.cell.2006.02.020
*cite journal | author=Kalesnikoff J, Rios EJ, Chen CC, "et al." |title=Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. |journal=Blood |volume=109 |issue= 12 |pages= 5308–17 |year= 2007 |pmid= 17341663 |doi= 10.1182/blood-2007-01-067363
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Delprato A, Lambright DG |title=Structural basis for Rab GTPase activation by VPS9 domain exchange factors. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 5 |pages= 406–12 |year= 2007 |pmid= 17450153 |doi= 10.1038/nsmb1232

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