Protein unc-119 homolog

Unc-119 homolog (C. elegans), also known as UNC119, is a human gene.cite web | title = Entrez Gene: UNC119 unc-119 homolog (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9094| accessdate = ]

PBB_Summary
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summary_text = This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: UNC119 unc-119 homolog (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9094| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Higashide T, Murakami A, McLaren MJ, Inana G |title=Cloning of the cDNA for a novel photoreceptor protein. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1797–804 |year= 1996 |pmid= 8576185 |doi=
*cite journal | author=Higashide T, McLaren MJ, Inana G |title=Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 5 |pages= 690–8 |year= 1998 |pmid= 9538874 |doi=
*cite journal | author=Swanson DA, Chang JT, Campochiaro PA, "et al." |title=Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 11 |pages= 2085–94 |year= 1998 |pmid= 9761287 |doi=
*cite journal | author=Higashide T, Inana G |title=Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119. |journal=Genomics |volume=57 |issue= 3 |pages= 446–50 |year= 1999 |pmid= 10329014 |doi= 10.1006/geno.1999.5791
*cite journal | author=Van Valkenburgh H, Shern JF, Sharer JD, "et al." |title=ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22826–37 |year= 2001 |pmid= 11303027 |doi= 10.1074/jbc.M102359200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cen O, Gorska MM, Stafford SJ, "et al." |title=Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8837–45 |year= 2003 |pmid= 12496276 |doi= 10.1074/jbc.M208261200
*cite journal | author=Kobayashi A, Kubota S, Mori N, "et al." |title=Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. |journal=FEBS Lett. |volume=534 |issue= 1-3 |pages= 26–32 |year= 2004 |pmid= 12527357 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gorska MM, Stafford SJ, Cen O, "et al." |title=Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. |journal=J. Exp. Med. |volume=199 |issue= 3 |pages= 369–79 |year= 2004 |pmid= 14757743 |doi= 10.1084/jem. 20030589
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Vepachedu R, Gorska MM, Singhania N, "et al." |title=Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. |journal=J. Immunol. |volume=179 |issue= 1 |pages= 682–90 |year= 2007 |pmid= 17579091 |doi=

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