CDC45-related protein

CDC45 cell division cycle 45-like (S. cerevisiae), also known as CDC45L, is a human gene.cite web | title = Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8318| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.cite web | title = Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8318| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Leatherwood J |title=Emerging mechanisms of eukaryotic DNA replication initiation. |journal=Curr. Opin. Cell Biol. |volume=10 |issue= 6 |pages= 742–8 |year= 1999 |pmid= 9914182 |doi=
*cite journal | author=Saha P, Thome KC, Yamaguchi R, "et al." |title=The human homolog of Saccharomyces cerevisiae CDC45. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18205–9 |year= 1998 |pmid= 9660782 |doi=
*cite journal | author=McKie JM, Wadey RB, Sutherland HF, "et al." |title=Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. |journal=Genome Res. |volume=8 |issue= 8 |pages= 834–41 |year= 1998 |pmid= 9724329 |doi=
*cite journal | author=Mimura S, Takisawa H |title=Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. |journal=EMBO J. |volume=17 |issue= 19 |pages= 5699–707 |year= 1998 |pmid= 9755170 |doi= 10.1093/emboj/17.19.5699
*cite journal | author=Shaikh TH, Gottlieb S, Sellinger B, "et al." |title=Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. |journal=Mamm. Genome |volume=10 |issue= 3 |pages= 322–6 |year= 1999 |pmid= 10051334 |doi=
*cite journal | author=Kukimoto I, Igaki H, Kanda T |title=Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. |journal=Eur. J. Biochem. |volume=265 |issue= 3 |pages= 936–43 |year= 1999 |pmid= 10518787 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111–28 |year= 2003 |pmid= 12614612 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, "et al." |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86–90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Liu P, Barkley LR, Day T, "et al." |title=The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30631–44 |year= 2006 |pmid= 16912045 |doi= 10.1074/jbc.M602982200
*cite journal | author=Masai H, Taniyama C, Ogino K, "et al." |title=Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39249–61 |year= 2007 |pmid= 17046832 |doi= 10.1074/jbc.M608935200
*cite journal | author=Boskovic J, Coloma J, Aparicio T, "et al." |title=Molecular architecture of the human GINS complex. |journal=EMBO Rep. |volume=8 |issue= 7 |pages= 678–84 |year= 2007 |pmid= 17557111 |doi= 10.1038/sj.embor.7401002
*cite journal | author=Bauerschmidt C, Pollok S, Kremmer E, "et al." |title=Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. |journal=Genes Cells |volume=12 |issue= 6 |pages= 745–58 |year= 2007 |pmid= 17573775 |doi= 10.1111/j.1365-2443.2007.01090.x
*cite journal | author=Pollok S, Bauerschmidt C, Sänger J, "et al." |title=Human Cdc45 is a proliferation-associated antigen. |journal=FEBS J. |volume=274 |issue= 14 |pages= 3669–84 |year= 2007 |pmid= 17608804 |doi= 10.1111/j.1742-4658.2007.05900.x
*cite journal | author=Pollok S, Grosse F |title=Cdc45 degradation during differentiation and apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 4 |pages= 910–5 |year= 2007 |pmid= 17767920 |doi= 10.1016/j.bbrc.2007.08.069

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