RCHY1

Ring finger and CHY zinc finger domain containing 1, also known as RCHY1, is a human gene.cite web | title = Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25898| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25898| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Beitel LK, Elhaji YA, Lumbroso R, "et al." |title=Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity. |journal=J. Mol. Endocrinol. |volume=29 |issue= 1 |pages= 41–60 |year= 2002 |pmid= 12200228 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leng RP, Lin Y, Ma W, "et al." |title=Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. |journal=Cell |volume=112 |issue= 6 |pages= 779–91 |year= 2003 |pmid= 12654245 |doi=
*cite journal | author=Logan IR, Sapountzi V, Gaughan L, "et al." |title=Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11696–704 |year= 2004 |pmid= 14701804 |doi= 10.1074/jbc.M312712200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Corcoran CA, Huang Y, Sheikh MS |title=The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest. |journal=Cancer Biol. Ther. |volume=3 |issue= 8 |pages= 721–5 |year= 2005 |pmid= 15280670 |doi=
*cite journal | author=Duan W, Gao L, Druhan LJ, "et al." |title=Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. |journal=J. Natl. Cancer Inst. |volume=96 |issue= 22 |pages= 1718–21 |year= 2004 |pmid= 15547185 |doi= 10.1093/jnci/djh292
*cite journal | author=Zhang L, Li J, Wang C, "et al." |title=A new human gene hNTKL-BP1 interacts with hPirh2. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 293–7 |year= 2005 |pmid= 15781263 |doi= 10.1016/j.bbrc.2005.02.156
*cite journal | author=Logan IR, Gaughan L, McCracken SR, "et al." |title=Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. |journal=Mol. Cell. Biol. |volume=26 |issue= 17 |pages= 6502–10 |year= 2006 |pmid= 16914734 |doi= 10.1128/MCB.00147-06
*cite journal | author=Duan W, Gao L, Wu X, "et al." |title=Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells. |journal=Exp. Cell Res. |volume=312 |issue= 17 |pages= 3370–8 |year= 2006 |pmid= 16934800 |doi= 10.1016/j.yexcr.2006.07.005
*cite journal | author=Duan S, Yao Z, Hou D, "et al." |title=Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. |journal=EMBO J. |volume=26 |issue= 13 |pages= 3062–74 |year= 2007 |pmid= 17568776 |doi= 10.1038/sj.emboj.7601749
*cite journal | author=Hattori T, Isobe T, Abe K, "et al." |title=Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. |journal=Cancer Res. |volume=67 |issue= 22 |pages= 10789–95 |year= 2007 |pmid= 18006823 |doi= 10.1158/0008-5472.CAN-07-2033

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