AKAP8

A kinase (PRKA) anchor protein 8, also known as AKAP8, is a human gene.cite web | title = Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10270| accessdate = ]

PBB_Summary
section_title =
summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.cite web | title = Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10270| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Eide T, Coghlan V, Orstavik S, "et al." |title=Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. |journal=Exp. Cell Res. |volume=238 |issue= 2 |pages= 305–16 |year= 1998 |pmid= 9473338 |doi= 10.1006/excr.1997.3855
*cite journal | author=Collas P, Le Guellec K, Taskén K |title=The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1167–80 |year= 2000 |pmid= 10601332 |doi=
*cite journal | author=Steen RL, Cubizolles F, Le Guellec K, Collas P |title=A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 531–6 |year= 2000 |pmid= 10791967 |doi=
*cite journal | author=Akileswaran L, Taraska JW, Sayer JA, "et al." |title=A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17448–54 |year= 2001 |pmid= 11279182 |doi= 10.1074/jbc.M101171200
*cite journal | author=Eide T, Carlson C, Taskén KA, "et al." |title=Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. |journal=EMBO Rep. |volume=3 |issue= 5 |pages= 426–32 |year= 2002 |pmid= 11964380 |doi= 10.1093/embo-reports/kvf089
*cite journal | author=Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H |title=AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50885–92 |year= 2003 |pmid= 12414807 |doi= 10.1074/jbc.M206387200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Eide T, Taskén KA, Carlson C, "et al." |title=Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26750–6 |year= 2003 |pmid= 12740381 |doi= 10.1074/jbc.M300765200
*cite journal | author=Arsenijevic T, Degraef C, Dumont JE, "et al." |title=A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 673–9 |year= 2004 |pmid= 14641107 |doi= 10.1042/BJ20031765
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Kamada S, Kikkawa U, Tsujimoto Y, Hunter T |title=A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. |journal=Mol. Cell. Biol. |volume=25 |issue= 21 |pages= 9469–77 |year= 2005 |pmid= 16227597 |doi= 10.1128/MCB.25.21.9469-9477.2005
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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