EIF4A3

Eukaryotic translation initiation factor 4A, isoform 3, also known as EIF4A3, is a human gene.cite web | title = Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9775| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.cite web | title = Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9775| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Miyajima N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=
*cite journal | author=Li Q, Imataka H, Morino S, "et al." |title=Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7336–46 |year= 1999 |pmid= 10523622 |doi=
*cite journal | author=Holzmann K, Gerner C, Pöltl A, "et al." |title=A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 339–44 |year= 2000 |pmid= 10623621 |doi= 10.1006/bbrc.1999.1973
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Lee S, Baek M, Yang H, "et al." |title=Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. |journal=Cancer Lett. |volume=184 |issue= 2 |pages= 197–206 |year= 2002 |pmid= 12127692 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chan CC, Dostie J, Diem MD, "et al." |title=eIF4A3 is a novel component of the exon junction complex. |journal=RNA |volume=10 |issue= 2 |pages= 200–9 |year= 2004 |pmid= 14730019 |doi=
*cite journal | author=Palacios IM, Gatfield D, St Johnston D, Izaurralde E |title=An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. |journal=Nature |volume=427 |issue= 6976 |pages= 753–7 |year= 2004 |pmid= 14973490 |doi= 10.1038/nature02351
*cite journal | author=Ferraiuolo MA, Lee CS, Ler LW, "et al." |title=A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 12 |pages= 4118–23 |year= 2004 |pmid= 15024115 |doi= 10.1073/pnas.0400933101
*cite journal | author=Shibuya T, Tange TØ, Sonenberg N, Moore MJ |title=eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 4 |pages= 346–51 |year= 2004 |pmid= 15034551 |doi= 10.1038/nsmb750
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Xia Q, Kong XT, Zhang GA, "et al." |title=Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 2 |pages= 526–32 |year= 2005 |pmid= 15796914 |doi= 10.1016/j.bbrc.2005.02.181
*cite journal | author=Ballut L, Marchadier B, Baguet A, "et al." |title=The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 10 |pages= 861–9 |year= 2005 |pmid= 16170325 |doi= 10.1038/nsmb990
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gehring NH, Kunz JB, Neu-Yilik G, "et al." |title=Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. |journal=Mol. Cell |volume=20 |issue= 1 |pages= 65–75 |year= 2005 |pmid= 16209946 |doi= 10.1016/j.molcel.2005.08.012
*cite journal | author=Andersen CB, Ballut L, Johansen JS, "et al." |title=Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. |journal=Science |volume=313 |issue= 5795 |pages= 1968–72 |year= 2006 |pmid= 16931718 |doi= 10.1126/science.1131981
*cite journal | author=You KT, Li LS, Kim NG, "et al." |title=Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. |journal=PLoS Biol. |volume=5 |issue= 5 |pages= e109 |year= 2007 |pmid= 17456004 |doi= 10.1371/journal.pbio.0050109
*cite journal | author=Zhang Z, Krainer AR |title=Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 28 |pages= 11574–9 |year= 2007 |pmid= 17606899 |doi= 10.1073/pnas.0704946104

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