RPL11

Ribosomal protein L11, also known as RPL11, is a human gene.cite web | title = Entrez Gene: RPL11 ribosomal protein L11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6135| accessdate = ]

PBB_Summary
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summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternative splice variants encoding different isoforms may exist, but they have not been fully characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPL11 ribosomal protein L11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6135| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=Mishin VP, Filipenko ML, Muravlev AI, "et al." |title= [Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11] |journal=Bioorg. Khim. |volume=21 |issue= 2 |pages= 158–60 |year= 1995 |pmid= 7748210 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Kenmochi N, Kawaguchi T, Rozen S, "et al." |title=A map of 75 human ribosomal protein genes. |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi=
*cite journal | author=Graphodatsky AS, Vorobieva NV, Filipenko ML, "et al." |title=Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1-->p35 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 97–8 |year= 1999 |pmid= 10343117 |doi=
*cite journal | author=Koldamova RP, Lefterov IM, DiSabella MT, "et al." |title=Human bleomycin hydrolase binds ribosomal proteins. |journal=Biochemistry |volume=38 |issue= 22 |pages= 7111–7 |year= 1999 |pmid= 10353821 |doi= 10.1021/bi990135l
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Voronina EN, Kolokol'tsova TD, Nechaeva EA, Filipenko ML |title= [Structural and functional analysis of the human ribosomal protein L11 gene] |journal=Mol. Biol. (Mosk.) |volume=37 |issue= 3 |pages= 425–35 |year= 2003 |pmid= 12815950 |doi=
*cite journal | author=Lohrum MA, Ludwig RL, Kubbutat MH, "et al." |title=Regulation of HDM2 activity by the ribosomal protein L11. |journal=Cancer Cell |volume=3 |issue= 6 |pages= 577–87 |year= 2004 |pmid= 12842086 |doi=
*cite journal | author=Odintsova TI, Müller EC, Ivanov AV, "et al." |title=Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. |journal=J. Protein Chem. |volume=22 |issue= 3 |pages= 249–58 |year= 2004 |pmid= 12962325 |doi=
*cite journal | author=Zhang Y, Wolf GW, Bhat K, "et al." |title=Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8902–12 |year= 2003 |pmid= 14612427 |doi=
*cite journal | author=Bhat KP, Itahana K, Jin A, Zhang Y |title=Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2402–12 |year= 2004 |pmid= 15152193 |doi= 10.1038/sj.emboj.7600247
*cite journal | author=Bernardi R, Scaglioni PP, Bergmann S, "et al." |title=PML regulates p53 stability by sequestering Mdm2 to the nucleolus. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 665–72 |year= 2004 |pmid= 15195100 |doi= 10.1038/ncb1147
*cite journal | author=Dai MS, Lu H |title=Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44475–82 |year= 2004 |pmid= 15308643 |doi= 10.1074/jbc.M403722200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Dai MS, Shi D, Jin Y, "et al." |title=Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. |journal=J. Biol. Chem. |volume=281 |issue= 34 |pages= 24304–13 |year= 2006 |pmid= 16803902 |doi= 10.1074/jbc.M602596200
*cite journal | author=Lindström MS, Jin A, Deisenroth C, "et al." |title=Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. |journal=Mol. Cell. Biol. |volume=27 |issue= 3 |pages= 1056–68 |year= 2007 |pmid= 17116689 |doi= 10.1128/MCB.01307-06

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